三种干细胞向雌性生殖细胞诱导的可行性探讨  

A review of three kinds of stem cells and their ability of differentiation to female germ cells

作　　者：周桦[1] 何志旭[2] 范安然[2] 周从容[1] 赵淑云[1] 黄官友[1] 

机构地区：[1]贵州医科大学附属医院生殖医学中心,贵阳550004 [2]贵州医科大学组织工程与干细胞实验中心,贵阳550004

出　　处：《生殖与避孕》2015年第11期800-805,820,共7页Reproduction and Contraception

摘　　要：雌性生殖细胞缺乏所致的不孕症目前尚无根本的治疗方法,干细胞的研究为这类患者带来了希望。随着胚胎干细胞(ESCs)/诱导性多能干细胞(iPSCs)建系技术的日趋成熟,体外诱导ESCs/iPSCs生成雌性生殖细胞的研究也取得了一定进展,目前已经有卵母细胞样细胞的形成,但所生成细胞的生殖生物学功能还有待进一步证实。近年来雌性生殖干细胞的发现及对其进一步的了解使获取更接近生理状态的卵子成为可能。本文对近年几种干细胞及其在生殖领域的研究进行综述,以探讨其临床应用的可行性。So far, there is no fundamental method to treat infertility which caused by the lack of female germ cells. However, researches on stem cells bring hope for such patients. With the maturing of technology on embryonic stem cells （ESCs）/induced pluripotent stem cells （iPSCs）, induction of female germ cells in vitro also has made a certain progress, and some oocytes-like cells have been produced. But reproductive function of those oocytes-like cells remains to be further confirmed. Studies of female germline stem cells may give us better eggs which have better physiological state. In this paper, several kinds of stem cells and recent researches of them in the field of reproduction will be described comprehensively, so we can investigate possibility of their application in clinic.

关 键 词：雌性生殖细胞 胚胎干细胞(ESCs) 诱导性多能干细胞(iPSCs) 雌性生殖干细胞 分化 

分 类 号：R711.6[医药卫生—妇产科学]