蒽环类药物心脏毒副作用机制及防治措施的研究进展  

The Research Progress on Cardiac Toxic Mechanism of Anthracyclines and Prevention Treatment Measures

作　　者：顾觉奋[1] 

机构地区：[1]中国药科大学生命科学与技术学院,南京210009

出　　处：《国外医药（抗生素分册）》2015年第6期241-248,255,共9页World Notes on Antibiotics

摘　　要：蒽环类抗肿瘤抗生素对多种恶性肿瘤均有效,但由于其心脏毒性在临床上的使用受到了严重限制。本文从蒽环类药物心脏毒性的作用机制(包括氧化应激、铁机制、钙失调、线粒体损伤、能量代谢障碍、细胞凋亡等等)及防治措施等方面综述了其研究进展。Anthracycline anticancer antibiotics was effective chemotherapy to a variety of malignant cancers, however, the clinical use was severely restricted due to its cardio toxicity. The mechanism of cardiac toxicity induced by anthracycline anticancer antibiotics（including oxidative stress, iron mechanism, calcium imbalance, mitochondrial damage, energy metabolic dysfunction, apoptosis and so on）, and its prevention treatment measures were reviewed.

关 键 词：蒽环类抗肿瘤药物 心脏毒性 作用机制 防治措施 

分 类 号：R979.1[医药卫生—药品]