糖尿病肾病患者血清脂肪特异性丝氨酸蛋白酶抑制剂水平及其相关因素的研究  

Association between serum vaspin and diabetic nephropathy

作　　者：刘平[1] 刘波[2] 王迪[2] 门晓彦 李莉[4] 刘博伟[2] 杨艳玲[2] 

机构地区：[1]河北省秦皇岛市第三医院,河北秦皇岛066000 [2]河北省秦皇岛市第一医院,河北秦皇岛066000 [3]河北省秦皇岛市海港医院,河北秦皇岛066004 [4]河北省秦皇岛市疾病预防控制中心,河北秦皇岛066001

出　　处：《中国临床医生杂志》2015年第11期30-32,共3页Chinese Journal For Clinicians

基　　金：秦皇岛市科学技术发展计划项目(201401A217)

摘　　要：目的探讨2型糖尿病患者血清中脂肪特异性丝氨酸蛋白酶抑制剂（Vaspin）的水平及其与糖尿病肾病的关系。方法随机选取50例健康对照者与96例2型糖尿病患者,根据24小时尿蛋白排泄率（UAER）分为DM组（UAER〈20μg/min）,微量白蛋白尿组（DN1组,UAER 20～200μg/min﹞和大量白蛋白尿组（DN2组,UAER〉200μg/min）。应用ELISA法测定血清Vaspin水平,同时测定空腹血糖（FBG）、空腹胰岛素（FINS）、血脂、糖化血红蛋白（Hb A1c）、尿素氮（BUN）、血肌酐（Cr）,采用稳态模型-胰岛素抵抗公式（HOMA-IR）评估胰岛素抵抗状态。结果血清Vaspin水平依次为对照组〈DN2组〈DN1组〈DM组，差异有显著性（P〈0．05）。DM组Vaspin水平与性别、甘油三酯（TG）、空腹血糖（FBG）、糖化血红蛋白（HbAlc）、空腹胰岛素（InFINS）、胰岛素抵抗指数（InHOMA—IR）、高密度脂蛋白胆固醇（HDL—c）显著相关（r值分别为0．561，0．239，0．521，0．593，0．320，0．225，-0．357，P〈0．05）。DN组Vaspin水平与FBG、InFINS、InHOMA—IR、性别显著相关（r值-0．532，-0．276，-0．239，0．537，P〈0．05）。Logistic回归分析显示：Vaspin、HbAlc、BMI、InHOMA—IR为糖尿病肾病的危险因素。结论Vaspin在糖尿病肾病的发生中起重要作用。Objective To explore the association between serum visceral adipose tissue derived serine protease inhibitor（ vaspin） and diabetic nephropathy. Method 94 type 2 diabetic patients and 50 controls were involved in this study. According to progression of nephropathy,patients with diabetes were divided into three groups： T2 DM group,microalbuminura group（ DN1 group,UAER20 ～ 200μg / min） and macroalbuminura group（ DN2 group,UAER 200μg / min）. Human body and biochemical parameters were measured. Serum vaspin were measured by ELISA.Result The levels of serum vaspin were significantly difference between four groups（ NC group DN2 group DN1 group DM group,P〈0. 05）. In the DM group,the level of vaspin was positively correlated with gender,TG,FBG,Hb A1 c,In FINS,In HOMA-IR（ r = 0. 561,0. 239,0. 521,0. 593,0. 320,0. 225,P〈0. 05）,and negatively correlated with HDL-C（ r =- 0. 357,P〈0. 05）. In the DN group,vaspin was negatively correlated with FBG、In FINS、In HOMA-IR（ r =- 0. 532,- 0. 276,- 0. 239,P〈0. 05）,and positively with gender（ r = 0. 537,P〈0. 05）. Logistic regression analysis showed that Hb A1 c,BMI,In HOMA-IR and serum vaspin were influential factors of diabetic nephropathy. Conclusion Vaspin plays a very important role in diabetic nephropathy.

关 键 词：2型糖尿病 脂肪特异性丝氨酸蛋白酶抑制剂 糖尿病肾病 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]