老年原发性肾病综合征患者临床病理特征及血清中炎性因子的表达  

Clinical and pathological characteristics and the expression of interleukin-6, interleukin-17 and tumor necrosis factor-α in elderly patients with primary nephrotic syndrome

作　　者：黄静蓉[1] 

机构地区：[1]青海大学附属医院肾病内科,810001

出　　处：《中华老年医学杂志》2015年第11期1207-1209,共3页Chinese Journal of Geriatrics

摘　　要：目的 探讨原发性肾病综合征老年患者的临床病理特征及血清中白细胞介素-6（IL-6）、白细胞介素-17（IL-17）和肿瘤坏死因子-α（TNF-α）的表达. 方法 选择原发性肾病综合征的老年患者75例为观察组,另选择无明显器质性疾病的老年人40例为对照组,抽取空腹静脉血检测血清中IL-6、IL-17和TNF-α的表达. 结果 75例患者中,有病理资料者67例,其中膜性肾小球肾炎46例,局灶节段性病变5例,系膜毛细血管性肾小球肾炎5例,系膜增生性肾小球肾炎和IgA肾病各3例,肾小球轻微及微小病变、硬化性肾小球肾炎、弥漫性增生性肾小球肾炎、节段增生性肾小球肾炎、轻微肾小球病变各1例.观察组和对照组IL-6、IL-17和TNF-α的表达差异有统计学意义;观察组不同病理特征患者中,IL-6和IL-17的表达差异无统计学意义,TNF-α表达在膜性肾小球肾炎患者中明显高于其他病理类型的患者. 结论 原发性肾病综合征老年患者的病理类型主要是膜性肾小球肾炎;老年肾病综合征患者血清中IL-6、IL-17和TNF-α的表达明显升高,TNF-α在膜性肾小球肾炎中的表达升高更为明显.Objective To investigate clinical and pathological characteristics and the expression of interleukin （IL）-6, IL-17 and tumor necrosis factor （TNF）-α in elderly patients with primary nephrotic syndrome.Methods A total of 75 elderly cases with primary nephrotic syndrome were chosen as the observation group, and 40 healthy elderly persons served as the control group.Fasting serum IL-6, IL-17 and TNF-α levels were measured by enzyme-linked immunosorbent assay （ELISA） for both groups.Results 67 of the 75 patients received pathological diagnoses, of whom 46 had membranous glomerulonephritis, 5 had focal segmental glomerulosclerosis, 5 had mesangiocapillary glomerulonephritis, 3 had mesangial proliferative glomerulonephritis, 3 had IgA nephropathy, and the rest included one case for each of the following disorders： glomerular minor lesion, sclerosing glomerulonephritis, diffuse proliferative glomerulonephritis, segmental proliferative glomerulonephritis, and minor glomerular lesions.The expression of IL-6, IL-17 and TNF-α had statistically significant differences between the two groups.There were no statistically significant differences in the expression of IL-6 and IL-17 between patients with different pathological characteristics, and the expression of TNF-α was higher in membranous glomerulonephritis patients than in patients with other pathological characteristics.Conclusions Membranous glomerulonephritis is the main pathological type in elderly patients with primary nephrotic syndrome.Serum IL-6, IL-17 and most notably TNF-α levels are elevated in patients with membranous glomerulonephritis.

关 键 词：肾病综合征 白细胞介素-6 白细胞介素-17 肿瘤坏死因子-Α 

分 类 号：R692[医药卫生—泌尿科学]