基于“中药作用机理辅助解析系统”的金钗石斛降糖作用机制研究  

Elucidating hypoglycemic mechanism of Dendrobium nobile through auxiliary elucidation system for traditional Chinese medicine mechanism

作　　者：李曼曼[1] 张百霞[1] 何帅兵[1] 郑娆[2] 张燕玲[1] 王耘[1] 

机构地区：[1]北京中医药大学中药信息工程研究中心,北京100102 [2]北京化工大学机电工程学院,北京100029

出　　处：《中国中药杂志》2015年第19期3709-3712,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81173568;81373985);教育部新世纪优秀人才支持项目(NECT-11-0605)

摘　　要：构建金钗石斛降糖生物网络,阐释金钗石斛治疗2型糖尿病的分子作用机制。检索数据库和文献整理金钗石斛中的化学成分,通过疾病相关数据库收集整理2型糖尿病相关靶点,利用"中药作用机理辅助解析系统",构建金钗石斛-2型糖尿病整体生物网络。通过对网络的分析,阐明金钗石斛治疗糖尿病的主要机制包括5个方面:1通过降低甘油三酯等调节脂质代谢;2减少胰岛素抵抗;3保护胰岛细胞;4促进葡萄糖依赖性促胰岛素释放肽(GIP)的分泌;5抑制钙离子通道。以网络药理学为指导,通过"中药作用机理辅助解析系统"初步阐明了金钗石斛降糖的分子作用机制,为金钗石斛的二次开发利用提供了依据。To build the Dendrobium nobile -T2DM network, and elucidate the molecular mechanism of D. nobile to type 2 diabetes （T2DM）. Collect the chemical composition of D. nobile and the targets on T2DM by retrieving database and documents, build the network of D. nobile to T2DM using the entity grammar systems inference rules. The molecular mechanism of D. nobile to T2DM includes ： ①regulating lipid metabolism by lowering triglyceride ; ②reducing insulin resistance ; ③protecting islet cells ; ④promoting the glucose-dependent insulin tropic peptide （GIP） secretion; ⑤inhibiting calcium channel. Under the guidance of network pharmacology, through entity grammar systems inference rules we elucidate the molecular mechanism of D. nobile to T2DM, and provide the basis for the further development of health care products based on D. nobile.

关 键 词：金钗石斛 2型糖尿病 中药 作用机制 辅助解析系统 实体语法系统 

分 类 号：R285[医药卫生—中药学]