基于“中药作用机理辅助解析系统”的丹参治疗心血管疾病作用机制解析  

Study on mechanism of Salvia miltiorrhiza treating cardiovascular disease through auxiliary mechanism elucidation system for Chinese medicine

作　　者：何帅兵[1] 张百霞[1] 王慧慧[1] 王耘[1] 乔延江[1] 

机构地区：[1]北京中医药大学中药信息工程研究中心,北京100102

出　　处：《中国中药杂志》2015年第19期3713-3717,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81173568;81373985);国家自然科学基金重点项目(81430094);教育部新世纪优秀人才支持项目(NECT-11-0605)

摘　　要：丹参作为临床上治疗心血管疾病的常用药物,虽然其治疗心血管疾病的作用机制已有研究,但是对其作用机制进行系统解析的报道却并不多见。该研究基于"中药作用机理辅助解析系统",综合数据挖掘技术,以生物反应数据库为背景构建丹参有效成分靶点与心血管疾病相关蛋白相互作用的分子网络,以期从网络药理学的角度系统解析丹参治疗心血管疾病的作用机制。结果表明,丹参主要通过以下10条途径来治疗心血管疾病:促进脂质代谢;抗炎;调节血压稳定;负向调节凝血因子;抗血栓形成;调节细胞增殖;抗应激损伤;促进血管新生;抑制细胞凋亡;调节血管收缩与扩张;促进伤口愈合。该研究结果较为系统地解析了丹参治疗心血管疾病的作用机制,为临床治疗心血管疾病新药的研发,尤其是中药组分配伍的现代中药研发提供了线索。Salvia miltiorrhiza is a traditional Chinese medicine （TCM） and is widely used as a clinically medication for its efficien- cy in treating cardiovascular disease. Due to TCM is a comprehensive system, the mechanism of S. miltiorrhiza treating cardiovascular disease through integrated multiple pathways are still unclear in some aspects. With the rapid progress of bioinformatics and systems bi- ology, network pharmacology is considered as a promising approach toward reveal the underlying complex relationship between an herb and the disease. In order to discover the mechanism of S. miltiorrhiza treating cardiovascular disease systematically, we use the auxilia- ry mechanism elucidation system for Chinese medicine, built up a molecule interaction network on the active component targets of S. miltiorrhiza and the therapeutic targets of cardiovascular disease to offer an opportunity for deep understanding the mechanism of S. miltiorrhiza treating cardiovascular disease from the perspective of network pharmacology. The results showed that S. miltiorrhiza treating cardiovascular disease through ten pathways as follows： improve lipid metabolism, anti-inflammation, regulate blood pressure, negatively regulates blood coagulation factor and antithrombotic, regulate cell proliferation, anti-stress injury, promoting angiogenesis, inhibited apoptosis, adjust vascular systolic and diastolic, promoting wound repair. The results of this paper provide theoretical guid- ance for the development of new drugs to treat cardiovascular disease and the discovery of new drugs through component compatibility.

关 键 词：丹参 心血管疾病 作用机制 实体语法系统 中药作用机理辅助解析系统 丹参酮ⅡA 

分 类 号：R259[医药卫生—中西医结合]