Brominelpara-Toluenesulfonic Acid-Catalyzed Synthesis of 3,3-Bis（indole-3-yl）indoline-2-（1H）-ones by Condensing Indoles with Isatins  

作　　者：Wenzhong Huang Lingli Nang Xiangguang Li Lin Yuan Yinhai Ma Deqiang Liang 

机构地区：[1]Department of Chemistry, Kunming University, Kunming, Yunnan 650214, China

出　　处：《Chinese Journal of Chemistry》2015年第10期1167-1172,共6页中国化学（英文版）

摘　　要：Under the catalysis of only 3 mol% of Br2 at room temperature, indoles reacted rapidly with isatins to form bio- logically important 3,3-bis（indole-3-yl）indoline-2-（1H）-ones with high efficiency and wide substrate scope. More- over, we demonstrated that p-toluenesulfonic acid （TsOH） could serve as a surrogate to catalyze this transformation.Under the catalysis of only 3 mol% of Br2 at room temperature, indoles reacted rapidly with isatins to form bio- logically important 3,3-bis（indole-3-yl）indoline-2-（1H）-ones with high efficiency and wide substrate scope. More- over, we demonstrated that p-toluenesulfonic acid （TsOH） could serve as a surrogate to catalyze this transformation.

关 键 词：homogeneous catalysis bromine effect indole functionalization C--C coupling alkylation 

分 类 号：TQ225.241[化学工程—有机化工] TS275.17[轻工技术与工程—农产品加工及贮藏工程]