α-硫辛酸对糖尿病慢性肾脏疾病患者尿足细胞标志蛋白及血管内皮生长因子的影响  

Effect ofɑ-lipoic acid on urinary podocalyxin and vascular endothelial growth factor in patients with chronic kidney disease in diabetes nephropathy

作　　者：董闪闪[1] 张洁[1] 刘璠[1] 贾新菊[1] 秘玉静[1] 周慧敏[1] 

机构地区：[1]河北医科大学第一医院内分泌科,石家庄050031

出　　处：《中国糖尿病杂志》2015年第11期962-965,共4页Chinese Journal of Diabetes

基　　金：河北省卫生厅重点科技研究计划(20130260)

摘　　要：目的探讨α-硫辛酸(ALA)对不同程度糖尿病慢性肾脏疾病(CKD)患者尿足细胞标志蛋白(PCX)及VEGF的影响。方法 186例T2DM患者根据UAER分为单纯糖尿病组(SDM组)、尿白蛋白微量组(NA组)、尿白蛋白大量组(MA组),NA组和MA组又分为ALA治疗组(NAⅠ组,MAⅠ组)及常规治疗组(NAⅡ组,MAⅡ组)。另选正常对照者(NC组)60名。比较各组ALA治疗前及治疗2周后尿PCX及血VEGF。结果 NAⅠ组ALA治疗后PCX[(17.65±3.05)vs(7.28±2.93)μg/L,P<0.01],VEGF[(453.94±36.17)vs(356.39±47.08)ng/L,P<0.01]下降,MAⅠ组ALA治疗后PCX[(26.95±5.41)vs(11.99±2.22)μg/L,P<0.01],VEGF[(550.65±46.76)vs(397.69±44.74)ng/L,P<0.01)]下降。结论 ALA可通过抗氧化应激(OS)保护肾小球足细胞。Objective To investigate the effect ofɑ-lipoic acid（ALA）on urinary podocalyxin（PCX）and vascular endothelial growth factor（VEGF）in different stages of chronic kidney disease（CKD）in diabetes. Methods A total of 246 participants were divided into four groups according to their UAER：normal control group（NC,n=60）,simple diabetes mellitus without nephropathy group（SDM,n=62）,micro albuminuria group（NA,n=60）and macro albuminuria group（MA,n=64）.NA and MA groups were also randomly divided into two groups ：ALA treatment group（NA Ⅰ,MA Ⅰ）and conventional treatment group（NA Ⅱ,MA Ⅱ）.The levels of urinary PCX and serum VEGF were determined at baseline and after 2 weeks＇ treatment. Results The levels of urinary PCX and serum VEGF were lower after ALA treatment than before ALA treatment in NAⅠ[（17.65±3.05）vs（7.28±2.93）μg/L,（453.94±36.17）vs（356.39±47.08）ng/L;P〈0.01]and MAⅠ[（26.95±5.41）vs（11.99±2.22）μg/L;（550.65±46.76）vs（397.69±44.74）ng/L,P〈0.01）]groups respectively. ConclusionALA can protect glomerular podocyte from injury,possibly due to its effects on alleviating enhanced oxidative stress（OS）.

关 键 词：糖尿病慢性肾脏疾病 Α-硫辛酸 尿足细胞标志蛋白 血管内皮生长因子 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]