女性绝经前后氧化低密度脂蛋白水平的比较及其相关因素分析  

Comparison of oxidized low-density lipoprotein and its related factors in premenopausal and postmenopausal women

作　　者：陈海兰[1] 高宇[1] 葛晓春[1] 宋娜[1] 冯增斌[1] 何建秋[1] 刘畅[1] 李丽慧[1] 刘晓燕[1] 

机构地区：[1]承德医学院附属医院内分泌科,067000

出　　处：《中国糖尿病杂志》2015年第11期1007-1009,共3页Chinese Journal of Diabetes

基　　金：河北省卫生厅科研基金项目(20130022)

摘　　要：目的比较女性绝经前后氧化低密度脂蛋白(ox-LDL)水平及其相关影响因素。方法根据75g OGTT将248例研究对象分为NGT、IGR及T2DM组。检测各组ox-LDL及其相关指标水平。结果 T2DM和IGR组ox-LDL水平高于NC组,且绝经后ox-LDL高于绝经前。绝经前ox-LDL与同型半胱氨酸(Hcy)、LDL-C、FPG呈正相关(β′=0.192、0.294、0.186,P=0.020、0.041、0.043);绝经后oxLDL与Hcy、LDL-C、FPG、SBP呈正相关(β′=0.159、0.165、0.578、0.220,P=0.002、0.022、<0.001、0.001),与HDL-C呈负相关(β′=-0.150,P=0.007)。结论围绝经期女性ox-LDL水平随糖耐量异常水平的增加而升高,绝经后女性ox-LDL与血脂、血糖及Hcy水平密切相关。Objective To compare the serum level of oxidized low-density lipoprotein（ox-LDL）and its related factors in premenopausal and postmenopausal women. Methods A total of 248 subjects were divided into three groups by 75 g OGTT as normal control（NC）group,IGR group and T2 DM group.Serum levels of ox-LDL and related factors were measured in each group. Results Serum levels of oxLDL were higher in T2 DM and IGR groups than in NC groups and also higher in postmenopausal women than in premenopausal women.Serum ox-LDL was positively correlated with Hcy,LDL-C and FPG in premenopausal women（β′=0.192,0.294,0.186,P=0.020,0.041,0.043）,and positively correlated with Hcy,LDL-C,FPG and SBP（β′=0.159,0.165,0.578,0.220,P=0.002,0.022,〈0.001,0.001）,and negatively correlated with HDL-C（β′=-0.150,P=0.007）in postmenopausal women. ConclusionSerum level of ox-LDL in perimenopausal women increases with the severity of glucose metabolism disorder.ox-LDL level was cbosely associated with blood lipids,blood glucose and Hcy in postmenopausal women.

关 键 词：女性 糖尿病 2型 氧化低密度脂蛋白 

分 类 号：R587.2[医药卫生—内分泌]