IgG4相关性疾病耳鼻咽喉病变的研究进展  

Review of ear and nose and throat involvement in IgG4-RD

作　　者：陶晓峰[1] 刘畅 宋波[3] 白艳[1] 付明杰[1] 孟津伊 

机构地区：[1]大连市中心医院病理科,辽宁大连116033 [2]大连市中一心医院风湿免疫科 [3]大连医科大学病理教研室

出　　处：《临床耳鼻咽喉头颈外科杂志》2015年第22期2015-2018,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金资助项目(No:81172052)

摘　　要：IgG4相关性疾病（IgG4-related disease,IgG4-RD）是近年被认识的一组新的疾病,其特征为：1个或多个器官的单发或多发肿块,病变组织中以IgG4＋浆细胞为主的淋巴浆细胞浸润,伴有席纹状纤维化和血清IgG4水平的升高。IgG4-RD可累及胰腺、肾脏、肺脏及腹膜后、前列腺等多个器官。以往关于IgG4-RD头颈部表现的报道主要为米库利兹病（Mikulicz disease,MD）、Küttner′s瘤、眼眶炎性假瘤及特发性肥厚性硬脑膜炎（idiopathic hyperlrophic pachymeningitis,IHP）等,但近来研究发现IgG4-RD也可伴有耳鼻咽喉部受累,并可能做为首发症状而就诊，极易漏诊和误诊，往往延迟治疗而给患者带来某些不可逆的损害。IgG4-related disease（IgG4-RD）is a newly recognized disease entity.IgG4-RD is characterized by a single or multiple masses in one or more organs;a lymphoplasmacytic infiltrate with a high percentage of plasma cells within the lesion staining for IgG4;apeculiar pattern of fibrosis known as＂storiform＂fibrosis;and elevated serum IgG4 concentrations.IgG4-RD can occur in various organs,including pancreas,kidneys,lungs,retroperitoneum,and prostate gland.The head and neck involvements of IgG4-RD have been chiefly described in Mikulicz disease（MD）,Küttner′s tumor,orbital？inflammatory pseudotumor,and idiopathic hypertrophic pachymeningitis（IHP）previously.Recent studies reported that IgG4-RD could also involve ear,nose and throat.Here we reviewed the literatures about ear,nose and throat involvement by IgG4-RD,in order to provide some theoretical bases for the diagnosis and treatment of IgG4-RD.

关 键 词：IGG4相关性疾病 

分 类 号：R762[医药卫生—耳鼻咽喉科]