MMP-9水平与慢性阻塞性肺疾病急性加重期肺功能变化相关性研究  

The Correlation of MMP -9 Level and Lung Function Changes in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：范荣梅[1] 邝军[1] 朱建勇[1] 张立波[1] 何敏[1] 叶青[1] 

机构地区：[1]湖北医药学院附属人民医院呼吸一病区,湖北十堰442000

出　　处：《医学新知》2015年第5期329-331,共3页New Medicine

摘　　要：目的探讨MMP-9在慢性阻塞性肺疾病急性加重期（AECOPD）中的变化及其与肺功能的相关性。方法选择AECOPD患者60例，根据肺功能及病情分为轻度、中度、重度组，每组20例，健康志愿者20例（对照组）。采用双抗夹心ELISA法，对各组AECOPD患者入院时血清MMP-9含量进行测定，并行肺功能检查。结果AECOPD各组血清MMP-9水平高于对照组，且随病情加重逐渐升高（P〈0．05）；其中轻度组MMP-9与中度、重度组之间差异有统计学意义（P〈0．05）。AECOPD各组患者血清MMP-9与FEV1％Pred、FEV1／FVC％均呈负相关。结论COPD组患者在急性加重期血清MMP-9水平均升高，并与疾病严重程度及气流受限程度有关，提示MMP-9是COPD患者肺功能下降的因素之一。Objective To explore the changes of MMP - 9 in acute exacerbation of chronic obstructive pulmona- ry disease（AECOPD） and its correlation with lung function. Methods 60 patients with AECOPD were divided into mild group, moderate group and severe group with 20 cases in each group according to lung function and condition with 20 healthy volunteers as control group. Double - antibody sandwich ELISA method was used to measure the con- tent of serum MMP - 9. Pulmonary function test was also conducted. Results The levels of serum MMP - 9 in AE- COPD group were higher than those in the control group, and increased with illness aggravating （ P 〈 0.05 ）. There were significant differences in MMP -9 between mild group and moderate group as well as severe group（ P 〈 0. 05 ）. Serum MMP- 9 in each group correlated with FEV1% Pred and FEV1/FVC% negatively. Conclusion The levels of MMP- 9 in patients with AECOPD are significantly increased, which are associated with the severity of disease and airflow limitation. It suggests that MMP -9 is one of the factors causing decrease of pulmonary function in patients with COPD.

关 键 词：慢性阻塞性肺疾病 基质金属蛋白酶一9 肺功能 

分 类 号：R563[医药卫生—呼吸系统]