高密度脂蛋白与心血管疾病关系的研究进展  

New Perspective of Relationship Between HDL and Cardiovascular Diseases Patient

作　　者：宋晓东[1] 王锦溪[1] 赵辉[1] 田雪晴[1] 

机构地区：[1]北京协和医学院中国医学科学院国家心血管病中心阜外医院,北京市100037

出　　处：《中国分子心脏病学杂志》2015年第5期1493-1496,共4页Molecular Cardiology of China

摘　　要：循环中低HDL-C水平被认为是动脉粥样硬化性心血管疾病(ASCVD)的主要危险因素。尽管HDL-C浓度与ASCVD风险具有较强的负相关性,近期大型研究显示药物升高HDL-C的干预手段未能减少心血管事件发生率,同时可能具有明显的不良反应。日益增加的证据支持HDL功能而非HDL-C浓度对于评价ASCVD风险、判断临床预后更有分析价值。将来的研究应当着眼于测量方法的标准化,并进一步阐释胆固醇外排能力(CEC)在预测疾病风险、反映治疗效果等方面的作用。Low levels of high-density lipoprotein cholesterol（HDL-C） in circulation have been shown to be an independent risk factor for ASCVD. Despite the strong reverse association between HDL-C concentration and ASCVD risk, recently large studies indicate that raising the levels of HDL-C may not lead to the decrease of the incidence of cardiovascular events and may have significant adverse effects. There are growing evidences supporting that the function of HDL instead of HDL-C level plays an essential role in evaluating ASCVD risk and clinical outcomes. Further studies are needed to standardize measurements and clarify the role cholesterol efflux capacity（CEC） may play in predicting risk of developing disease and response to therapies.

关 键 词：HDL-C 胆固醇外排能力 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]