非糖尿病人群载脂蛋白A/B和冠状动脉病变相关性研究  

The Correlation Study between Apolipoprotein A/B and Coronary Lesions in Patients with non Diabetic Population

作　　者：周烨[1] 金鸣锋[1] 陈广华[1] 杜荣增[1] 钱骏[1] 吴骏[1] 严金川[1] 

机构地区：[1]江苏大学附属医院,江苏镇江212000

出　　处：《中外医学研究》2015年第32期5-7,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨非糖尿病人群载脂蛋白(Apo)A/B及其相关脂质指标与冠状动脉病变的关系。方法:选取2014年在笔者所在医院行冠脉造影术的352例患者,根据冠状动脉造影结果将其分为对照组、冠状动脉粥样硬化组及冠心病组。比较三组的总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、Apo A、Apo B、Apo A/B,分析脂质指标与代表冠状动脉病变程度的Gensini积分的关系。结果:三组在性别、年龄、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、Apo A方面比较,差异均无统计学意义(P>0.05),冠状动脉粥样硬化组的Apo B较对照组升高,差异有统计学意义(P<0.05),Apo A/B较对照组下降,差异有统计学意义(P<0.01)。冠心病组的LDL-C、Apo B、Apo A/B与对照组比较,差异均有统计学意义(P<0.01)。Gensini积分与Apo A、Apo A/B呈负相关,与LDL-C、Apo B呈正相关。结论:本研究显示非糖尿病人群Apo A/B和冠状动脉病变严重程度呈负相关。Objective： To investigate the relationship between apolipoprotein （Apo） A/B and its related lipid associated indicators and the coronary artery lesions in non-diabetic population.Method： 352 patients were selected in our hospital in 2014, according to the coronary angiography results, they were divided into the control group, the coronary atherosclerosis group and the coronary heart disease group.The total cholesterol（TC）,triglyceride（TG）, high density lipoprotein cholesterol（HDL-C）, low density lipoprotein cholesterol（LDL-C）, ApoA, ApoB and ApoA/B of the three groups were compared, the relationship between lipid parameters and on behalf of the coronary artery lesion severity Gensini score was analyzed.Result： There were no significance in gender, age, TC, TG, HDL-C and ApoA between the three groups.ApoB of the coronary atherosclerosis group was higher than that the control group , the difference was statistically significant（P〈0.05）; and ApoA/B was decreased, there was statistically significant difference （P〈0.01）; LDL-C, ApoB, ApoA/B of the coronary atherosclemsis group were higher than those of the control group , the differences were statistically significant （P〈0.01）.Gensini score was negatively correlated with the ApoA and ApoA/B, and positively correlated with LDL-C and ApoB.Conclusion： This research shows that ApoA/B is negatively correlated with the severity of coronary lesions in non-diabetic population.

关 键 词：载脂蛋白 冠状动脉造影 GENSINI积分 

分 类 号：R541.4[医药卫生—心血管疾病]