双特异性抗体药物应用进展  

Application of Bispecific Antibody Drugs

作　　者：李耿[1] 刘晓志[1] 王志明[1] 高健[1] 

机构地区：[1]华北制药集团新药研究开发有限责任公司抗体药物研制国家重点实验室,石家庄050015

出　　处：《生物技术进展》2015年第6期420-424,共5页Current Biotechnology

基　　金：国家科技重大专项项目(2012ZX09101313);河北省重大科技成果转化专项(13042404Z)资助

摘　　要：基因工程的飞速发展推动了新型双功能抗体药物的成功研制。目前双功能抗体药物主要应用于肿瘤的免疫治疗、自身免疫疾病和感染类疾病的治疗,在组织再生和临床诊断领域也有应用。就双特异性抗体的发展史进行了简要回顾,对其在免疫治疗、组织再生和临床诊断等领域中的应用进展进行了综述,并展望了未来的发展方向,以期为新型双特异性抗体药物的研制提供参考。Rapid development of gene engineering has led to the success of the new type of bispecific antibody drugs. At present,the application of dual bispecific antibody drugs was in tumor immunotherapy,autoimmune diseases,infectious diseases,tissue regeneration and clinical diagnosis. In this paper,the brief development history was introduced,and applications of bispecific antibodies in immunological therapy,tissue regeneration and clinical diagnosis were reviewed. At last,development prospect was forecasted. The paper was expected to provided reference for the research and development of new bispecific antibody drugs.

关 键 词：BiTE(T-细胞的双特异抗体) 双特异性抗体 免疫治疗 组织再生 

分 类 号：TQ464[化学工程—制药化工]