研究肠道菌群的模式生物--秀丽隐杆线虫  

Caenorhabditis elegans: an model organism for gut flora-host interactions research

作　　者：于周龙 高艳[2] 张成岗[1,2] 

机构地区：[1]广西医科大学,南宁530021 [2]军事医学科学院放射与辐射医学研究所,蛋白质组学国家重点实验室,全军军事认知与心理卫生研究中心,北京100850

出　　处：《军事医学》2015年第10期794-796,801,共4页Military Medical Sciences

基　　金：国家重点基础研究发展计划资助项目(2012CB518200);国家自然科学基金资助项目(81371232,81100979,81070741)

摘　　要：肠道微生物对人体健康有着重要的作用,与营养物质吸收和肥胖、糖尿病等代谢性疾病关系密切。从肠道微生物的角度研究疾病发生及防治方法已成热点。高等动物模型存在个体差异大、肠道微生物种类繁多、数量庞大、影响因素多变等弊端。秀丽隐杆线虫(Caenorhabditis elegans),简称线虫,是研究肠道微生物和宿主之间相互作用的良好模式生物,其以大肠杆菌为食物,具有生长周期短、表型易于观察、可实现药物的高通量筛选等优点。如利用线虫模型筛选具有抗致病菌感染的益生菌,同时揭示多种细菌间的相互作用机制。该文对秀丽线虫在肠道微生物与宿主共生关系及相关应用研究进展进行综述。Gut microbes play an important role in human health and are believed to be closely related to obesity, diabetes and some other metabolic diseases. Recently, intestinal flora has become a research hotspot and new target for disease prevention. The problems facing intestinal flora research included variability between individuals, huge amounts and varieties of gut microbes. Caenorhabditis elegans, with the advantages of living on E. coli, short growth periods, easy observation, applicability to high throughput screening of drugs, is an ideal model organism for research of microbe-host interactions. It has been used in probiotics screening and interaction mechanism research of multifold bacteria. This review summarizes some new researches and applications in this area.

关 键 词：秀丽线虫 肠道菌群 衰老 大肠杆菌 

分 类 号：R378[医药卫生—病原生物学]