BNP对老年不稳定型心绞痛患者近期预后的预测价值  

Prognostic value of B-type natriuretic peptide in elderly patients with unstable angina

作　　者：李静[1,2] 黄婼[2] 张燕群[2] 孟冉[2] 安毅[3] 

机构地区：[1]青岛大学,山东省青岛市266000 [2]莱芜市人民医院干部科,山东省莱芜市271100 [3]青岛大学附属医院心内科,山东省青岛市266000

出　　处：《实用老年医学》2015年第11期902-904,共3页Practical Geriatrics

摘　　要：目的探讨B型利钠肽（BNP）对老年不稳定型心绞痛（unstable angina,UA）患者6月内主要不良心血管事件的预测价值。方法选择≥70岁UA患者120例,测定BNP水平,按BNP〉80 pg/ml和BNP≤80 pg/ml分为2组。随访6月,观察终点记录主要不良心血管事件,包括再发心绞痛、非致死性心肌梗死或心力衰竭、恶性心律失常（室性心动过速、室颤）、心源性死亡。结果 BNP〉80 pg/ml组患者主要不良心血管事件发生率明显高于BNP≤80 pg/ml组患者（39.6%比22.2%）,差异有统计学意义（P〈0.01）。Logistic多因素分析显示,BNP独立预测UA患者6月主要不良心血管事件,OR值为1.871,95%CI为1.394~2.511。结论 BNP对老年UA患者近期预后有独立的预测价值,可作为危险分层的重要指标,指导临床的治疗决策。Objective To evaluate the value of B-type natriuretic peptide（ BNP） in elderly patients with unstable angina（ UA）. Methods 120 patients with UA aged 70 years and over were enrolled in this study. BNP was examined at the time of admission. All patients were divided into two groups,one group with BNP 80 〉pg / ml and another with BNP≤80 pg / ml. All patients were followed up for 6 months for major adverse cardiovascular events,including recurrent angina,new acute myocardial infarction or congestive heart failure,malignant arrhythmia and cardiac death. Results The patients with BNP 〉80 pg / ml were at higher risk of major adverse cardiovascular events than those with BNP≤80 pg / ml（ 39. 6% vs 22. 2%）. Multinomial Logistic regression showed that BNP was an independent predictor for major adverse cardiovascular events in 6 months [OR（ 95% CI） ： 1. 871（ 1. 394-2. 511） ]. Conclusions BNP might be a biochemical marker and prognosis indicator in elderly patients with UA.

关 键 词：B型利钠肽 不稳定型心绞痛 老年人 

分 类 号：R541.4[医药卫生—心血管疾病]