二氢槲皮素抗炎抗过敏止痒作用的活性研究  

Study on taxifolin's activities of anti-inflammatory,anti-allergc and relieving itching

作　　者：蔡华君[1] 郑毅男[1] 刘文丛[1] 

机构地区：[1]吉林农业大学中药材学院,吉林长春130118

出　　处：《人参研究》2015年第3期32-35,共4页Ginseng Research

摘　　要：目的研究二氢槲皮素抗炎、抗过敏、止痒的作用。方法利用二甲苯致小鼠耳肿胀法,观察其抗炎作用;利用2,4-二硝基氯苯(DNCB)诱导小鼠迟发性超敏反应(DTH),观察其抗过敏作用;利用4-氨基吡啶(4-AP)诱导小鼠皮肤过敏性瘙痒,观察其止痒作用。结果二氢槲皮素能显著对抗二甲苯所致小鼠耳肿胀和降低DNCB诱导的小鼠过敏反应有显著改善作用,并且能明显减少4-AP诱导的瘙痒反应的舔体次数。结论二氢槲皮素有显著的抗炎、抗过敏、止痒作用。Study on taxifolin＇s anti-inflammatory, anti-allergic and relieving itching. Methods： Use xyleneinduced ear edema in mice method, anti-inflammatory effect was observed; the use of 2,4-Dinitrochlorobenzene（DNCB） in mice induced delayed type hypersensitivity（DTH）, to observe the anti-allergic effect; use4-Aminopyridine（4-AP） mice induced allergic skin itching, itching to observe its effect. Results： taxifolin can antagonize the xylene induced mouseear swelling and reduced DNCB induced anaphylaxis in mice have significant improvement, and can significantly reduce the number of licking itch reaction induced by 4-AP. Conclusion： taxifolin has significant anti-inflammatory, anti-allergic, anti-itch effect.

关 键 词：二氢槲皮素 抗炎 抗过敏 止痒 

分 类 号：R285.5[医药卫生—中药学]