复方益母草口服液联合缩宫素预防阴道分娩产妇产后出血及促进子宫复旧的效果与安全性  

Efficacy and Safety of Compound Yimucao Oral Liquid Combined with Oxytocin in the Prevention of Postpartum Hemorrhage and Promotion of Uterine Involution for Puerpera of Vaginal Delivery

作　　者：张伟[1] 杜国辉[1] 曹冬梅[1] 谢巍[1] 钱坤[1] 于桂兰[1] 姜海英[2] 

机构地区：[1]唐山市妇幼保健院药剂科,河北唐山063000 [2]唐山市妇幼保健院妇产科,河北唐山06300

出　　处：《中国药房》2015年第33期4629-4631,共3页China Pharmacy

摘　　要：目的：观察复方益母草口服液联合缩宫素预防阴道分娩产妇产后出血及促进子宫复旧的效果与安全性。方法：240例经产道自然分娩的产妇随机均分为对照组和观察组。对照组产妇分娩后,臀部立即注射缩宫素20 U。观察组患者在对照组的基础上加服复方益母草口服液20 ml,每日3次,连续服用两周。观察两组产妇产后阴道出血、子宫复旧及不良反应发生情况。结果：观察组产妇产后1 h出血量、1~2 h出血量、产后42 d复查时宫底高度与对照组比较,差异均无统计学意义（P〉0.05）;观察组产妇产后2~24 h出血量、产后出血的发生率,产后42 d复查时子宫体大小、宫腔积血情况、恶露持续时间均显著优于对照组,差异均具有统计学意义（P〈0.05）。两组产妇均未见发热、皮疹、恶心等明显药物不良反应发生。结论：复方益母草口服液联合缩宫素能明显减少阴道分娩产妇产后出血、促进子宫复旧,且安全性较好。OBJECTIVE：To observe the efficacy and safety of Compound yimucao oral liquid combined with oxytocin in the prevention of postpartum hemorrhage and promotion of uterine involution for puerpera of vaginal delivery. METHODS：240 pregnants with natural childbirth of vaginal delivery were randomly divided into control group and observation group. Control group was injected oxytocin 20 U in buttock after delivery. Observation group was additionally treated with Compound yimucao oral liquid 20 ml,tid for consecutive 2 weeks. Postpartum vaginal bleeding,uterine involution and incidence of adverse reactions in 2 groups were observed. RESULTS：Compared with control group,postpartum hemorrhage volume after delivery 2-24 h,incidence of postpartum hemorrhage,uterus size,uterine hemorrhage and lochia duration in postpartum 42 d in observation group were significantly better than control group,the differences were statistically significant（P〈0.05）;there were no significant differences in the hemorrhage postpartum volume after delivery 1 h and 1-2 h and fundal height in postpartum 42 d in 2 groups（P〉0.05）. There were no fever,rash,nausea and other obvious adverse reactions in 2 groups. CONCLUSIONS：Compound yimucao oral liquid combined with oxytocin can obviously decrease the postpartum bleeding and promote uterine involution,with good safety.

关 键 词：复方益母草口服液 缩宫素 阴道分娩 产后出血 子宫复旧 疗效 安全性 

分 类 号：R287.4[医药卫生—中药学]