放射治疗对早期鼻咽癌患者骨导听阈的影响  

Effects of radiotherapy on bone conduction hearing thresholds in early stage nasopharyngeal carcinoma

作　　者：郭明坤[1] 薛鸣[2] 张珂[3] 

机构地区：[1]新乡市中心医院耳鼻咽喉科,新乡453000 [2]新乡市中心医院放疗科,新乡453000 [3]河北大学附属医院胸外科,保定071000

出　　处：《中华耳科学杂志》2015年第3期522-524,共3页Chinese Journal of Otology

摘　　要：目的探讨放射治疗对早期鼻咽癌患者骨导听阈的影响。方法收集2006年2月至2012年3月在我院治疗且资料完整的32例早期鼻咽癌患者,分别记录患者放疗前、放疗后1.5年及放疗后2年双耳0.5、1、2、4 k Hz四个语言频率骨导听阈值及畸变产物耳声发射,并对记录的数据进行统计分析。结果患者双耳0.5、1、2、4 k Hz四个语言频率骨导阈值放疗后1.5年及放疗后2年均高于放疗前,且三者差异有统计学意义(P<0.05)。放疗后1.5年及放疗后2年患者DPOAE检查未通过率增高,且差异有统计学意义(P<0.05)。结论放疗可以使早期鼻咽癌患者骨导阈值提高,对于鼻咽癌放疗患者应尽早积极防治,避免感音神经性听力损失。Objective To investigate radiation-induced sensorineural hearing loss in early nasopharyngeal carcinoma. Methods Clinical data of patients with nasopharyngeal carcinoma treated by the authors from February 2006 to March 2012 were collected. Conventional pure tone audiometry test was conducted.DPOAE and bone conduction thresholds were recorded for frequencies of 0.5, 1, 2 and 4 k Hz to compare hearing before and at 1.5 and 2 years after radiotherapy. Thresholds were examined separately for each frequency.Results Bone conduction thresholds before radiotherapy were lower than those at 1.5 and 2 years after radiotherapy. The differences were statistically significant for all frequencies（P〈0.05）. At 1.5 and 2 years after radiotherapy, DPOAE failing rate increased（P〈 0.05）. Conclusion This study shows that the bone conduction threshold increases significantly in patients with early stage nasopharyngeal carcinoma treated with radiotherapy. All measures of prevention and treatment should be considered as early as possible in patients with nasopharyngeal carcinoma who are receiving radiotherapy to prevent advance of sensorineural hearing loss.

关 键 词：鼻咽癌 放射治疗 骨导 听阈 听力损失 

分 类 号：R812[医药卫生—放射医学]