HSP70、NF-κB与子痫前期发病的关系  

The relationship between HSP70,NF-κB and preeclampsia

作　　者：林培红[1] 

机构地区：[1]福州市第一医院妇产科,福州350009

出　　处：《中国当代医药》2015年第31期13-15,20,共4页China Modern Medicine

摘　　要：子痫前期的发病机制是产科研究的热点,胎盘的基础研究是子痫前期病因学研究的焦点之一。子痫前期胎盘形态学发生改变,同时胎盘组织的多种蛋白质表达亦发生各种改变,其介导或对抗炎症、氧化应激反应,损伤或保护细胞,维持平衡状态,使妊娠得以继续。热休克蛋白70、核因子-κB在胎盘着床和发育、调节内皮功能、炎症反应、氧化应激等方面均有一定的作用,与子痫前期发病密切相关。本文简要综述国内外相关报道,为探讨子痫前期的发病机制及治疗提供新思路。Pathogenesis of preeclampsia is a hot issue in the research of obstetrics,The placenta of basic research is one of the focus of preeclampsia etiology.The morphology of placenta changes at preeclampsia,meanwhile,various changes occur in the expression of a variety of protein in placenta.They mediate or fight against inflammation,and ox- idative stress,damage or protect cells,maintaining the equilibrium state,which allows the pregnancy to be continued. HSP70 and NF-κB play a role in the implantation and development of placenta,regulating the endothelial function,in- flammation,oxidative stress,etc.It is closely related to the pathogenesis of preeclampsia.This article briefly reviews the relevant reports at home and abroad and provide new ideas to explore the pathogenesis and treatment of preeclampsia.

关 键 词：子痫前期 炎症反应 氧化应激 热休克蛋白70 核因子-ΚB 

分 类 号：R714.12[医药卫生—妇产科学]