自制万古霉素质控血清用于血药浓度监测的可行性探讨  

Self-made vancomycin quality-control serum applied in blood drug concentration monitoring

作　　者：董富祥[1] 马爱玲[1] 秦玉花[1] 

机构地区：[1]河南省人民医院药学部,郑州450003

出　　处：《中国临床药理学杂志》2015年第22期2252-2253,共2页The Chinese Journal of Clinical Pharmacology

摘　　要：目的探讨自制万古霉素质控血清在血药浓度监测中应用的可行性。方法取注射用盐酸万古霉素1.0 mg,注射用水溶解后加入血清基质液,制备质量浓度分别为10,20,30μg·m L^-1万古霉素质控血清并检测其浓度,考察方法准确性、质控样品的稳定性及临床应用。结果自制低、中、高浓度的万古霉素质控血清检测结果为靶值的98.0%~101.5%,-30℃保存6个月含量变化小于2%。结论自制万古霉素质控血清操作方法简单、成本低、结果准确可靠,可以作为实验室日常质量控制。Objective To evaluate self- made vancomycin quality - control serum used in blood drug concentration monitoring. Methods To prepare 10,20,30 μg·m L^-1 vancomycin quality - control serum. The preparation, repeatability, sample stability and clinical application were studied. Results The results of low, medium and high concentra- tion of vancomycin quality - control serum was 98.0% - 101.5%. The content change of vancomycin was less than 2% while saved at - 30 ℃ within 6 months. Conclusion The method for preparation of self - made vancomycin quality - control serum is simple, cost - effective, accurate and reliable, which can be used as daily laboratory quality control saved at - 30℃.

关 键 词：万古霉素 血药浓度 质量控制 

分 类 号：R978.1[医药卫生—药品]