血清β-人绒毛膜促性腺激素、C-反应蛋白和新嘌呤水平与足月胎膜早破孕妇羊膜感染的相关性研究  

Study on the correlation between serum β-human chorionic gonadotropin,C-reactive protein,new purine levels and amniotic infection among pregnant women with term premature rupture of membranes

作　　者：付丽娟[1] 吕胜江[1] 付海龙[1] 孙占宇[1] 

机构地区：[1]山东省昌邑市人民医院检验科,261300

出　　处：《中国妇幼保健》2015年第33期5756-5759,共4页Maternal and Child Health Care of China

摘　　要：目的观察和分析血清β-人绒毛膜促性腺激素(β-h CG)、C-反应蛋白(CRP)和新嘌呤(Npt)水平与足月胎膜早破(PROM)孕妇合并羊膜感染的相关性。方法选取150例足月PROM孕妇作为研究对象,根据是否存在羊膜感染将纳入的孕妇分为感染组57例和非感染组93例。对两组孕妇产前的血清β-h CG、CRP、Npt水平进行检测和比较。结果感染组患者的血清β-h CG、CRP、Npt水平均高于非感染组,两组之间的差异均有统计学意义(t=4.128、6.713、3.925,均P<0.05);应用上述三种血清指标联合检测诊断足月PROM合并羊膜感染的敏感度均显著高于单独应用,差异有统计学意义(χ2=12.755、11.528、9.205,均P<0.05),而应用三种血清指标联合和单独应用一种指标检测诊断足月PROM合并羊膜感染的特异度差异无统计学意义(χ2=1.632,P>0.05);感染组孕妇的血清β-h CG水平与其血清CRP水平和Npt水平呈正相关关系(r=0.516、0.463,P<0.05),其血清CRP水平与血清Npt水平呈正相关关系(r=0.582,P<0.05)。结论足月PROM合并羊膜感染孕妇表现为血清β-h CG、CRP、Npt水平的显著升高,上述三种血清指标具有良好的相关性,而且进行联合检测时可提高诊断的敏感度,可作为诊断的辅助指标。Objective To observe and analyze the correlation between serum β-human chorionic gonadotropin （β-hCG） , C-re- active protein （CRP）, new purine （Npt） levels and amniotic infection among pregnant women with term premature rupture of membranes （tPROM） . Methods A total of 150 tPROM pregnant women were selected as study objects, then they were divided into infection group （57 cases） and non-infection group （93 cases） according to accompanying with amniotic infection or not. The levels of serum β-hCG, CRP, and Npt before delivery in the two groups we,＇e detected and compared. Results The levels of serum β-hCG, CRP, and Npt in infection group were statistically significantly higher than those in non-infection group （t = 4. 128, P〈0. 05; t = 6. 713, P〈0. 05; t = 3.925, P〈 0. 05 ） . The sensitivity of joint detection of the three indexes in diagnosis of tPROM combined with amniotic infection were statistically significantly higher than those of single detection of each index （X2 =12. 755, P〈0. 05 ; = 1l. 528, P〈0. 05 ; X2 = 9. 205, P〈0.05 ）, but there was no statistically significant difference in the specificity between joint detection of the three indexes and single detection of each index （X2 = 1. 632, P〉0. 05 ） ; in infection group, serum 13-hCG level was positively eorrelated with serum CRP level （ r=0. 516, P〈0.05 ; ） and serum Npt level （ r=0. 463, P〈0.05 ） , serum CRP level was positbcely correlated with serum Npt level （ r=0. 582, P〈0.05 ） . Conclusion The levels of serum β-hCG, CRP, and Npt in pregnant women with tPROM combined with amniotie infeetion inerease signifieantly, the a-hove-mentioned serum indexes have good correlations, and joint detection can increase the sensitivity, which can be used as auxiliary diagnostic indexes.

关 键 词：胎膜早破 Β-人绒毛膜促性腺激素 C-反应蛋白 新嘌呤 羊膜感染 

分 类 号：R714.413[医药卫生—妇产科学]