羧甲基壳聚糖在药物缓释和组织工程学中的应用新进展  

Recent Advances of Carboxymethyl Chitosan in Targeted Drug Delivery and Tissue Engineering Applications

作　　者：程浩南[1] 

机构地区：[1]江西服装学院工程分院,南昌330201

出　　处：《材料导报》2015年第21期137-144,共8页Materials Reports

摘　　要：羧甲基壳聚糖(CMCS)作为一种新型且具有广泛应用前景的生物聚合物在药物缓释系统、组织工程学、医用支架装置等再生医学领域的应用和研究得到了广泛的关注,作为生物聚合物材料,其在生命科学领域的应用正在迅速发展。CMCS是一种双亲性醚,它由甲壳素衍生而来,具有高水溶性、优良的生物相容性、可控的生物降解性、骨再生性等物理化学和生物特性。除此之外,CMCS还可以装载拒水性药物且展现出较强的生物活度,这使它广泛用在不同药物缓释材料系统的制备和细胞组织培养方面。本文对基于CMCS的几种新型聚合物的药物缓释特性、修复治疗特征方面做出了详细解读,并进一步简述其制备工艺和不同器官或组织的应用。文章最后指出CMCS类生物聚合物遇到的应用限制及挑战,并提出展望。Over the last decade carboxymethyl chitosan （CMCS） has emerged as a promising biopolymer for the development of new drug delivery systems and improved scaffolds along with other tissue engineering devices for regenerative medicine that is currently one of the most rapidly growing fields in the life sciences. CMCS is amphiprotic ether, derived from chitosan, exhibiting enhanced aqueous solubility, excellent biocompatibility, controllable biodegradability, osteogenesis ability and numerous other outstanding physicochemical and biological properties. More strikingly, it can load hydrophobic drugs and displays strong bioactivity which highlight its suitability and extensive usage for preparing different drug delivery and tissue engineering formulations respectively. This review provides a comprehensive introduction to various types of CMCS based formulations for delivery of therapeutic agents and tissue regeneration and further describes their preparation procedures and applications in different tissues/organs. The article then, gives a brief account of therapy combining drug delivery and tissue engineering. Finally, identification of major challenges and opportunities for current and ongoing application of CIVICS based systems in the field are summarized.

关 键 词：羧甲基壳聚糖 药物缓释 组织工程学 再生医学 生物活度 

分 类 号：O636.9[理学—高分子化学]