健康孕期妇女百日咳鲍特菌毒素IgG抗体水平分析  

Prevalence of pertussis infection in Chinese pregnant women measured by IgG antibody against pertussis toxin

作　　者：韩锐郡[1] 颜晖[2] 刘莹[1] 习艳丽[1] 高源[3] 王增国[1] 

机构地区：[1]西安市疾病预防控制中心,陕西西安710054 [2]西安市中心医院,陕西西安710002 [3]中国疾病预防控制中心传染病所,北京102206

出　　处：《热带医学杂志》2015年第10期1329-1331,共3页Journal of Tropical Medicine

摘　　要：目的分析孕期妇女百日咳毒素(PT)IgG抗体水平,并评价近期感染百日咳的可能。方法采用定量ELISA方法检测154例健康孕期妇女怀孕初期以及怀孕后期双份血清PT-IgG。结果所有标本PT-Ig G均<100 IU/ml,其中72例(46.8%)受试者在临产前PT-IgG<5 IU/ml。4例受试者的双份血清PT-IgG滴度发生2倍以上的下降。估算孕期妇女近期的百日咳年感染率为4.5%(365.25/208.9×2.6%)。结论孕期妇女的PT-IgG滴度较低,成年育龄妇女在怀孕前可能自然感染百日咳,其感染率可能被低估。Objective To analyze of pregnant women pertussis toxin（PT） IgG antibody levels and evaluate the possibility of a recent pertussis infection. Methods Total of 154 pregnant women were enrolled to detect the PT-IgG antibody at the beginning and the ending of pregnancy. PT-IgG was measured by the serion ELISA kits. Results Seventy-two out of 154 subjects at the ending of pregnancy had the anti-PT IgG titer lower than 5 IU / ml. No sample was detected with the anti-PT IgG≥ 100 IU / ml; there were 4 sample pairs have a ≥2-fold decrease of anti-PT IgG. The estimated incidence of infection was4.5%（365.25 / 208.9×2.6%） per year for the pregnant women. Conclusion It seems that the nature infection of pertussis in Chinese pregnant women is possibly underestimated. The average anti-PT IgG titer among the pregnant women is low.

关 键 词：百日咳毒素 抗体 自然感染 

分 类 号：R378.42[医药卫生—病原生物学]