皮层下动脉硬化性脑病和维生素D水平的相关性研究  

CORRELATIONS BETWEEN SERUM 25( OH) D LEVELS AND SUBCORTICAL ARTERIOSCLEROTIC ENCEPHALOPATHY

作　　者：杨文彬 庄建伟 林红 

机构地区：[1]东莞市清溪医院,广东东莞523660

出　　处：《现代医院》2015年第3期36-37,40,共3页Modern Hospitals

基　　金：东莞市科学技术局科研立项(编号:20140515000261)

摘　　要：目的探讨皮质下动脉硬化性脑病(SAE)患者的血清维生素D水平及其与年龄、血糖、血脂、血压和胰岛素水平的关系。方法选择100例SAE患者和50例健康人群,采用酶联免疫吸附法测定两组患者血清25(OH)D水平以及血压、空腹血糖、血脂和胰岛素水平,并进行两组间的比较。结果与健康组相比,SAE组患者收缩压、舒张压、空腹血糖、总胆固醇、胰岛素水平显著升高,血清25(OH)D水平显著降低,差异具有统计学意义(p<0.05,p<0.01)。甘油三酯、脂蛋白差异无显著性(p>0.05)。SAE组患者血清25(OH)D水平与年龄、收缩压、舒张压和空腹血糖负相关(p<0.05,p<0.01)。与甘油三酯、脂蛋白、胆固醇和胰岛素水平无相关性(p>0.05)。结论皮质下动脉硬化病患者的血清25(OH)D水平降低,可能通过影响机体能量代谢参与皮质下动脉硬化性脑病的发生和发展。Objective To explore the correlations between the levels of serum 25 （OH）D and age, blood sugar, blood lipid, blood pressure and insulin levels in patients with subcortical arteriosclerotic encephalopathy. Methods A total of 100 patientswith subeortical arteriosclerotic eneephalopathy （SAE） and 50 healthy persons were enrolled in the study. ELISA was adopted to determine serum 25 （OH） D levels in two groups. Meantime, fasting glu- cose, blood lipid, blood pressure and insulin levels were measured and compared between two groups. Results The systolic blood pressure, diastolic blood pressure, fasting glucose, total cholesterol and insulin levels in SAE patients were significantly higher than those in the healthy control （p 〈 0.05 ）. The serum 25 （OH）D levels in SAE patients were significantly lower than that in the healthy control（p 〈 0.01 ）. There were no significant differences in triglycer- ide and lipoprotein between two groups （p 〉 0.05 ）. The serum 25 （ OH ） D levelswere negatively related with age, SBP, DBP and fasting glucose（p 〈 0.05 ,p 〈 0.01 ） but not correlative with TC, TG, LDL, HDL, and insulin levels in SAE patients. Conclusion The serum 25 （OH）D levels in SAE patients are reducedby playing a regulative role in the occurrence and development of SAE throughaffectingthe energy metabolism.

关 键 词：皮质下动脉硬化性脑病 维生素D 血清25(OH)D 相关性 

分 类 号：R587.1[医药卫生—内分泌]