Broca语言区长期缺如下的BOLD功能磁共振代偿研究  

The research of brain compensatory mechanism with the long-term absence of Broca region by BOLD-fMRI

作　　者：李敏[1] 刘树永[1] 李玉报[1] 张霞[1] 

机构地区：[1]泰山医学院附属泰山医院医学影像部,山东泰安271000

出　　处：《泰山医学院学报》2015年第5期486-489,共4页Journal of Taishan Medical College

基　　金：山东省优秀中青年科学家科研奖励基金(BS2012YY033)

摘　　要：目的探讨Broca语言区长期缺如下的脑内代偿情况。方法左侧Broca区因外伤脑出血切除缺如患者6例,手术后5~10年不等,平均6年10个月。男：女=2：1,年龄26~54岁,平均42.5岁。正常健康志愿者20人,男10例,女10例,平均34.5岁,均为右利手。检查者均完成图片命名任务。AFNI软件处理实验数据。统计分析采用SPSS20.0分析软件。同一感兴奋区比较采用两样本均数t检验。结果与正常对照组比较：双侧颞上回后部（BA22区）激活体素及强度明显升高,有统计学意义;双侧顶上小叶、小脑半球、梭状回,左侧角回及辅助运动区激活强度明显提高,激活体素明显减少,有统计学意义。结论 Broca语言区长期缺如下,脑内多个脑区参与了语言功能的代偿。Objective：To explore the functional compensation and plasticity mechanism when the left Broca region is absent for a long time. Methods：The patients’ group of 6 cases,whose left Broca regions were resected because of the hem-orrhage after the trauma,were examined in 5-10Y after the operation with the average age of 6Y and 10M,and the rate between male and female was 2：1,with age between 26-54Y at mean age of 42. 5Y. The 20 cases of normal healthy vol-unteers had 10 males and 10 females with the mean age of 34. 5Y. The right hand was predominant. The tasK of picture na-ming was done. The same regions in two groups were compared with two sample paired t test. The experiment data were dealt with AFNI soft ware and analysed with SPSS 20. 0. Results：Compared with the normal group,the activatated voxels and activated intensity were increased obviously in both sides of superior temporal gyrus,and had the statistical signifi-cance. Activated intensity was increased and activated voxels were decreased in the both side of superior parietal lobe,cer-ebellar hemisphere,fusiform gyrus,left angular gyrus and supplementary motor area,and also had the statistical signifi-cance. Conclusion：Many brain regions participate in the functional compensation of the language when the Broca region is absent for a long time.

关 键 词：Broca语言区长期缺如 Bold-功能磁共振 

分 类 号：R445.2[医药卫生—影像医学与核医学]