机构地区:[1]沈阳市第六人民医院感染病科,110006 [2]内蒙古通辽市传染病医院 [3]黑龙江齐齐哈尔市第七人民医院感染科 [4]哈尔滨市传染病医院感染科 [5]辽宁省大连市第六人民医院感染科 [6]辽宁省丹东市传染病医院感染科 [7]辽宁省抚顺市传染病院感染科 [8]辽宁省铁岭市中心医院感染科 [9]辽宁省阜新市传染病医院感染科 [10]辽宁省辽阳市传染病医院感染科
出 处:《中华临床感染病杂志》2015年第5期419-424,共6页Chinese Journal of Clinical Infectious Diseases
摘 要:目的:比较2014年我国东北地区不同年龄组麻疹患者流行及临床特征差异。方法连续收集东北地区2014年1至6月10家传染病医院收治住院的麻疹患者的病例资料,将患者分为<16岁组和≥16岁组,对所有病例的流行病学、临床特征、治疗及转归情况进行回顾性分析。采用SPSS 17.0统计软件对数据进行比较。结果共收集到1401例麻疹患者,其中<16岁组402例,≥16岁999例。主要的临床表现有充血性斑丘疹(100.0%)、发热(84.58%)、咳嗽(85.80%)、科氏斑(73.23%)、咽充血(71.23%)、腹泻(43.97%)、咳痰(40.97%)、流泪(39.40%)和流涕(30.55%)。<16岁组患者科氏斑、咳痰、咽充血、腹泻的发生率低于≥16岁组患者,差异具有统计学意义(χ2=8.364、29.768、10.953和6.701,P<0.05或<0.01),但流涕的发生率高于≥16岁组患者,差异亦有统计学意义(χ2=6.703,P<0.05)。患者血常规、C-反应蛋白( CRP)、肝肾功能、电解质、心肌酶谱等指标存在异常,<16岁组外周血 WBC 升高或下降、PLT 和肌酸激酶同工酶升高分别为38例(9.45%)、105例(26.12%)、122例(30.35%)和279例(69.40%),均高于≥16岁组患者,分别为45例(4.5%)、202例(20.22%)、14例(1.40%)和347例(34.73%),差异具有统计学意义(χ2=12.593、5.830、274.033和139.385,P<0.05或<0.01);<16岁组患者丙氨酸转氨酶( ALT)、总胆红素水平( TBil)、肌酸激酶( CK)和CRP升高分别为70例(17.41%)、7例(1.74%)、38例(9.45%)和7例(1.74%),而白蛋白(Alb)、K+、Na+、Cl-下降,分别为214例(53.23%)、59例(14.68%)、45例(11.19%)和94例(23.38%),异常率均低于≥16岁组,分别为668例(66.87%)、89例(8.91%)、277例(27.73%)、714例(71.47)和268例(26.83%)、339例(33.93Objective To investigate the epidemiological and clinical characteristics of measles in patients of different age groups in Northeast China in 2014.Methods The clinical data of patients with measles in ten hospitals of infectious diseases in Northeast China from January 2014 to June 2014 were collected.Patients were divided into 〈16 age group and ≥16 age group, and the epidemiology , clinical characteristics, treatment and prognosis of all patients were retrospectively reviewed .SPSS 17.0 was used for data analysis.Results There were 1 401 patients with measles, in which 402 were 〈16-year old, and 999 were ≥16-year old.Clinical manifestations were mainly maculopapule (100.0%), fever (84.58%), cough (85.80%), Koplik’ s spot (73.23%), pharyngeal hyperemia (71.23%), diarrhea (43.97%), expectoration (40.97%), tears (39.40%) and runny nose (30.55%).The incidences of Koplik’s spot, sputum, pharyngeal hyperemia and diarrhea in 〈16 age group were lower than those in ≥16 age group (χ2 =8.364, 29.768, 10.953 and 6.701, P〈0.05 or 〈0.01); while the incidence of runny nose was higher than that in ≥16 age group (χ2 =6.703, P〈0.05).Abnormalities were found in blood routine examination, C-reactive protein (CRP), liver and kidney function, serum electrolyte levels, myocardial enzymes, and so on.Increasing in WBC, PLT and creatine kinase isoenzyme (CKMB), and decreasing in WBC were observed in 38(9.45%), 122(30.35%), 279(69.40%) and 105(26.12%), patients in 〈16 age group, which were higher than those in ≥16 age group [45(4.5%), 14(1.40%), 347(34.73%) and 202(20.22%)], and the differences were of statistical significance (χ2 =12.593, 274.033, 139.385 and 5.830, P〈0.05 or P〈0.01).Increasing in alanine aminotransferase (ALT), CRP, total bilirubin level (TBil), creatine kinase (CK), and decreasing in albumin (Alb), K+, Na+, Cl-were observed in 70(17.41%), 7(1.74%), 38(9.45%), 7(1.
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