树突状细胞治疗42例核苷(酸)类似物和(或)干扰素经治慢性乙型肝炎患者的临床研究  

Dendritic cells treatment on 42 chronic hepatits B patients treated with nucleos(t)ide and(or) interferon

作　　者：顾生旺 高凯旋 刘欢 周曙 吴德平 张金荣 蒋兆荣 焦峰 王建国 

机构地区：[1]江苏省淮安市解放军第八二医院感染内科,江苏淮安223001 [2]江苏省淮安市解放军第八二医院中心实验室,江苏淮安223001 [3]江苏省淮安市解放军第八二医院医务处,江苏淮安223001

出　　处：《中国肝脏病杂志（电子版）》2015年第3期85-88,共4页Chinese Journal of Liver Diseases：Electronic Version

基　　金：中国人民解放军第八二医院2014年度院管课题(2014-002)

摘　　要：目的探讨树突状细胞(dendritic cells,DC)治疗核苷(酸)类和(或)干扰素经治慢性乙型肝炎降低HBs Ag、HBe Ag定量效果。方法自体血分离培养树突状细胞(DC)回输治疗核苷(酸)类和(或)干扰素经治慢性乙型肝炎(CHB)42例,并与348例对照组比较HBs Ag、HBe Ag定量变化情况。结果 DC治疗组与对照组HBs Ag下降显效率分别为28.2%、18.9%;HBe Ag定量下降显效率分别为41%和29.6%,二组HBe Ag下降显效率无显著差异(P=0.31)。结论自体DC回输可以打破部分慢性乙型肝炎患者的免疫耐受,诱导一定的免疫应答,提高乙型肝炎综合抗病毒治疗效果。Objective To investigate the effect of dendritic cells （DC） on reducing HBsAg and HBeAg levels of chronic hepatitis B （CHB） patients treated with nucleoside （nucleotide） and （or） interferon. Methods Autologous dendritic cells were separated and cultured and re-infused into 42 cases of respective CHB patients who had been treated with nucleos（t）ide and （or） interferon. Their HBsAg and HBeAg levels were compared with those 348 patients in control group. Results Markedly effective rates of the reduction of HBsAg levels were 28.2% in treatment group and 18.9% in control group, while those of the reduction of HBeAg levels in both groups were 41% and 29.6%, respectively. No significant difference in markedly effective rate of HBeAg reduction was found between the two groups （P = 0.31）. Conclusions Re-infusion of autologous dendritic cells can break immune tolerance in part of the CHB patients and induce some immune response, and enhance the comprehensive effect of antiviral treatment for hepatitis B.

关 键 词：树突状细胞 肝炎 乙型 表面抗原 E抗原 核苷(酸)类似物 

分 类 号：R512.62[医药卫生—内科学]