人类免疫缺陷病毒与人乳头瘤病毒共感染的临床特征分析  

Analysis on the clinical characteristics of human immunodeficiency virus and human papilloma virus co-infection

作　　者：司炎辉[1] 刘保池[1] 黄朝刚[1] 

机构地区：[1]上海市公共卫生临床中心外科,上海201508

出　　处：《中华实验和临床感染病杂志（电子版）》2015年第5期54-57,共4页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：国家"十一五"传染病重大专项(No.2008ZX10001-015)

摘　　要：目的研究HIV感染者合并人乳头瘤病毒(HPV)感染的临床特征和治疗方法。方法对83例尖锐湿疣合并HIV感染者的临床资料做回顾性分析。根据术前CD4+T淋巴细胞水平,将入组83例患者分为人类免疫缺陷综合征(AIDS)组34例(CD4<200 cell/μl)和HIV感染组49例(CD4>200 cell/μl),比较两组患者的临床特征和治疗疗效。结果艾滋病组的CD4+T淋巴细胞数和CD4/CD8值,显著低于HIV感染组(t=-7.79、-2.70,P均<0.05);艾滋病组中19例伴有其他并发症(56%),14例形成巨型尖锐湿疣(41%),其中3例发生癌变;3个月内有16例复发(47%)。HIV感染组中11例有其他合并症(22%),5例巨型尖锐湿疣(10%),术后3个月内10例复发(20%)。结论 AIDS患者合并HPV感染易形成巨型尖锐湿疣而且容易发生其他并发症。彻底切除病变结合应用抗逆转录病毒药物,可以取得较好的疗效,降低复发率。Objective To study the relationship of the seriousness of immune deficiency and clinical characteristics for the patients of condyloma acuminatum with human immunodeifciency virus （HIV） infection, and to explore better treatment methods.Methods The clinical data of 83 cases of condyloma acuminatum combined HIV infection were analyzed, retrospectively. According to the detection of CD4＋T lymphocyte level in preoperative, they were divided into AIDS group with 34 cases （CD4 〈 200 cell/μl） and HIV infection group with 49 cases （CD4 〉 200 cell/μl）. The clinical features and treatment effect of patients in the two groups were compared, respectively.Results CD4＋T lymphocyte count and CD4/CD8 ratio in AIDS groups were signiifcantly lower than that of HIV infection group （t=-7.79 and-2.70,P all 〈 0.05）. In AIDS group, there were 19 （56%） cases with other infections, there were 14 （41%） cases with giant condyloma and 3 with cancerous of them. Three months after surgery, there were 16 （47%） patients relapsed in AIDS group. In HIV infection group, there were 11 （22%） cases with other infections, 5 （10%） cases with giant condyloma and 10 （20%） cases were recurrence three months after surgery.Conclusions Condyloma acuminatum in AIDS patients with low immunity is easy to form a giant condyloma acuminate and prone to other infections. Electrosurgical knife resection with the use of anti-retroviral therapy, could obtain better curative effect, reduce the recurrence rate.

关 键 词：人类免疫缺陷病毒 人类乳头状瘤病毒 尖锐湿疣 抗逆转录病毒治疗 复发 

分 类 号：R512.91[医药卫生—内科学]