降钙素原检测在感染性疾病诊断中的价值  

Clinical value of procalcitonin in diagnosis of infectious diseases

作　　者：张敏[1] 陈浩[1] 曹明[1] 

机构地区：[1]保定市传染病医院防保科,保定市071000

出　　处：《中华实验和临床感染病杂志（电子版）》2015年第5期105-107,共3页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

摘　　要：目的评价血清降钙素原在细菌感染性疾病诊断中的价值。方法收集保定市传染病医院疑为感染的患者其中细菌组94例患者,病毒组38例患者,以102例健康人群为对照。采用上转发光免疫层析法检测血清中降钙素原(PCT)和C-反应蛋白(CRP)水平。结果病毒感染组患者PCT与健康组相比轻度升高,但差异无统计学意义(F=0.325、P=0.078);病毒感染组与健康组患者CRP水平差异具有统计学意义(F=68.13、P=0.007);细菌感染组与其他各组相比,PCT和CRP水平均显著升高。细菌感染组PCT和CRP的阳性率要显著高于病毒感染组,差异均具有统计学意义(χ2=66.16、P=0.001,χ2=48.77、P=0.002)。病毒感染组PCT的阳性率显著低于CRP。应用ROC曲线分析PCT和CRP鉴别诊断细菌感染的效能,曲线下面积分别为0.854和0.783,PCT效能优于CRP。结论在诊断病原微生物的感染中,PCT是一个很好的血清指标,用于细菌感染诊断和鉴别诊断。Objective To evaluate the clinical significance of serum procalcitonin （PCT） in the diagnosis of bacterial infection diseases. Methods There were 94 cases with bacterial infection and 38 cases with viral infection group were selected, while 102 healthy ones were selected as control group. The levels of serum PCT and CRP were detected by the up-converting phoshor technology immunochromatography, respectively.Results The levels of PCT of patients in virus infections group compared with healthy group were mildly elevated, but with no significant difference （F = 0.325, P = 0.078）. The levels of CRP of patients in virus infection group compared with the control group had a signiifcant difference （F = 68.13, P = 0.007）. The levels of PCT and CRP of patients in bacterial infection group compared with other groups were increased signiifcantly. The levels of PCT and CRP of patients in positive rate of bacterial infection group were signiifcantly higher than virus infection group （χ2= 66.16,P = 0.001;χ2= 48.77,P = 0.002）. The positive rates of PCT of patients in virus infection group were signiifcantly lower than that of CRP. The ROC curves of PCT and CRP in differential diagnosis of bacterial infection of the effectiveness were analyzed, the area under the curve were 0.854 and 0.783, PCT was more effective than CRP.Conclusions In the diagnosis of pathogenic microorganism infection, PCT is a good index of serum used in the diagnosis and differential diagnosis of bacterial infection.

关 键 词：降钙素原 细菌感染 C-反应蛋白 

分 类 号：R446.6[医药卫生—诊断学]