不同干扰素药物治疗慢性丙型肝炎近期疗效的比较  

The short-term effect comparison of different interferon drugs on patients with chronic hepatitis C

作　　者：张海燕[1] 范晖[2] 

机构地区：[1]江苏省如皋市人民医院感染科,如皋市226500 [2]江苏省如皋市人民医院肿瘤科,如皋市226500

出　　处：《中华实验和临床感染病杂志（电子版）》2015年第5期120-122,共3页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

摘　　要：目的分析不同干扰素药物治疗慢性丙型肝炎的近期疗效。方法选择2009年8月至2014年8月于本院就诊的慢性丙型肝炎患者共80例,随机分为研究组(40例)和对照组(40例)。研究组患者给予Peg IFN-α-2a治疗,对照组患者给予IFN-α-2b治疗。治疗前进行HCV、抗-HCV、RNA定量、肝功能和血常规指标检测。治疗后对患者的血常规、尿素氮、肌酐、尿常规、甲状腺功能以及心电图复查。治疗4、12、24周分别监测两组患者的HCV RNA定量。记录治疗期间患者不良情况的发生率。结果治疗第4、12、24周时,两组患者的外周静脉血HCV载量、AST以及ALT水平均较治疗前有显著下降,差异具有统计学意义(第4周:t=2.012、P=0.046,t=2.351、P=0.025;t=2.757、P=0.009;第12周:t=2.181、P=0.039,t=2.334、P=0.027,t=2.351、P=0.025;第24周:t=2.811、P=0.007,t=3.012、P=0.005,t=3.527、P=0.002)。治疗第4周时,研究组患者治疗HCV病毒载量较对照组低,差异具有统计学意义(t=2.233、P=0.036);研究组患者的RVR显著优于对照组患者,差异具有统计学意义(χ2=3.982、P=0.023)。结论 Peg IFN-α-2a治疗的RVR高于IFN-α-2b,但是两种方法的ETR、生物化学应答率、EVR以及不良反应发生率差异并无统计学意义。Objective To analyze the short-time effect of different drugs on patients with chronic hepatitis C.Methods Total of 80 patients with chronic hepatitis C were selected in our hospital from August 2009 to August 2014. All patients were randomly divided into study group （40 cases） and control group （40 cases）. Patients in study group＆#39;s received PegIFN-α-2a therapy while the control group treated with IFN-α-2b. Before treatment, the levels of HCV, anti-HCV, quantitative detection of RNA, liver function and blood routine index were detected. After the treatment, blood routine, blood urea nitrogen, creatinine, urine routine, thyroid function of patients were reviewed, respctively. After 4, 12 and 24 weeks, HCV RNA quantitative were monitor of patients in two groups. The incidence of adverse events during the treatment period was recorded.Results At the treatment of 4, 12 and 24 weeks, patients in the two groups with peripheral venous blood HCV load, AST and the amount of ALT were all signiifcantly decreased, with signiifcant differences （The fourth week：t = 2.012, P = 0.046;t = 2.351, P = 0.025; t = 2.757,P = 0.009. Twelfth weeks： t = 2.181, P = 0.039;t = 2.334,P = 0.027; t = 2.351, P = 0.025; Twenty-fourth weeks：t = 2.811,P = 0.007;t = 3.012,P = 0.005;t= 3.527,P = 0.002）. After 4 weeks, HCV viral load of patients in study group was lower than that in control group, with signiifcance difference （t = 2.233, P= 0.036）. RVR of patients in the study group＆#39;s was signiifcantly better than that the patients in the control group, with signiifcance difference （t= 2.233,P= 0.036）. Conclusions PegIFN-α-2a treatment of RVR is higher than IFN-α-2b, but the levels of ETR, biochemical response rate, EVR and the incidence of adverse reactions after treated with the two methods were with no signiifcant differences.

关 键 词：干扰素 肝炎 丙型 慢性 疗效 

分 类 号：R512.63[医药卫生—内科学]