儿童脑膜炎患者血清降钙素原水平与血C-反应蛋白的关系研究  

Research on relationship between the levels of serum procalcitonin and C-reactive protein in children with meningitis

作　　者：武静[1] 于瑞杰[1] 

机构地区：[1]泰安市妇幼保健院检验科,山东泰安271000

出　　处：《中国实验诊断学》2015年第11期1872-1874,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨儿童脑膜炎患者血清降钙素原(PCT)水平的变化及其与C-反应蛋白(CRP)的关系。方法检测44例脑膜炎患儿血清PCT水平,其中化脓性脑膜炎患儿12例,病毒性脑膜炎患儿32例,同时测定其血CRP、白细胞(WBC)及脑脊液相关指标[蛋白、WBC、氯化物及葡萄糖],并做统计学分析。结果化脓性脑膜炎组血清PCT水平为(9.30±20.47)μg/L,明显高于病毒性脑膜炎组[(0.37±0.27)μg/L](P<0.01);脑膜炎患儿血清PCT与CRP、脑脊液蛋白、WBC呈明显正相关[相关系数(r)分别为0.343、0.437、0.439,P均<0.05),与氯化物呈负相关(r=-0.387,P<0.01);进一步多元回归分析显示,血CRP(β=0.648,P<0.01)影响了40.5%的PCT变化,且PCT也是脑膜炎患儿CRP水平的决定因素之一。结论化脓性脑膜炎患儿血清PCT水平明显升高。升高的PCT与CRP的增加有一定关联,可能通过参与细菌感染诱导的炎症反应促进化脓性脑膜炎的发生、发展。Objective To investigate the relationship between the level change of serum procalcitonin （PCT） and C- reactive protein （CRP） in children with meningitis. Methods The levels of serum PCT in 41 children with purulent（n = 12） or viral（n= 32） meningitis were determined, the levels of CRP, white blood cell （WBC） and cerebrospinal fluid related indicators[-protein,WBC, chloride and glucose] were determined simultaneously, and the results were analyzed statistically. Results The PCT levels in purulent meningitis group [-（9.30 ± 20.47） μg/L] were significantly higher than those in viral meningitis group [（0.37±0.27） μg/L] （P〈0.01）. The PCT levels in children with meningitis were positively correlated with CRP,cerebrospinal fluid protein and WBC[correlation coefficient （r）= 0. 343,0. 437 and 0. 439 ,P〈0.05], and negatively with chloride （r= -0. 387, P〈0.01）. Multiple linear regression analysis found that the change of CRP（β=0. 648, P〈0.01） influenced the 40.5 % of the change of PCT. In addition, PCT was one of factors for the CRP levels in children with meningitis. Conclusion The levels of serum PCT in 41 children with puru lent meningitis increase significantly,which are associated with the increase of CRP, promoting the occurrence and de velopment of purulent meningitis by participating in the bacterial infection-induced inflammatory response.

关 键 词：降钙素原 C-反应蛋白 炎症 脑膜炎 儿童 

分 类 号：R725.1[医药卫生—儿科]