微波辅助活性MnO_2选择氧化葡甲苷合成葡萄糖醛酸  

Synthesis of Glucuronic Acid by Selective Oxidation of Methyl Glucoside with Active MnO_2 under Microwave

作　　者：吴加雄[1] 袁华[1] 张培[1] 张华良[1] 吴元欣[1] 

机构地区：[1]武汉工程大学化工与制药学院绿色化工过程教育部重点实验室,湖北武汉430073

出　　处：《合成化学》2015年第11期1056-1059,共4页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21276201);武汉工程大学研究生教育创新基金资助项目(CX2014113)

摘　　要：葡甲苷经微波辅助MnO2一级选择氧化和H2O2二级氧化合成了葡萄糖醛酸,其结构经HPLC和LC-MS确证。探索了不同反应条件对收率的影响。结果表明:活性MnO2在微波辐射条件下具有较好的氧化活性和选择性,反应时间短。最佳合成条件为:活性MnO2为氧化剂,水为溶剂,于80℃微波(400 W)反应2 h,葡甲苷和活性二氧化锰质量比为1∶4,收率79%。Glucuronic acid was synthesized by selective oxidation with active MnO2 under the microwave radiation and oxidation with H2O2 from methyl glucoside. The structure was confirmed by HPLC and LC-MS. The effects of different oxidative conditions on the yield were studied. The results showed that active MnO2 exhibited good oxidative activity and selectivity under the microwave radiation,and greatly shortened the reaction time. The optimum reaction conditions were as followed： active MnO2 as the oxidant,mass ratio of methyl glucoside and active MnO2 was 1 ∶ 4,under microwave（ 400 W）,at 80 ℃ for 2 h,the yield was 79%.

关 键 词：葡甲苷 活性MnO2 选择氧化 微波辐射 葡萄糖醛酸 合成 

分 类 号：O643.3[理学—物理化学] TQ426[理学—化学]