MR T2弛豫时间评估颈椎间盘退变的初步研究  

Measurement of MR T2 relaxation time for assessing cervical intervertebral disc degeneration: preliminary study

作　　者：黄耀渠[1] 赵晓梅[1] 伍琼惠[1] 秦红卫[1] 

机构地区：[1]广东省佛山市中医院MRI室,佛山528000

出　　处：《磁共振成像》2015年第11期843-847,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：广东省医学科研基金课题(编号:A2013680);佛山市科技局医学攻关课题(编号:201308015)

摘　　要：目的：探讨MRI测量T2弛豫时间定量评估颈椎间盘退变及年龄、节段相关变化的价值。材料与方法40名健康受试者进行了颈椎常规MRI和T2-mapping检查。对椎间盘进行Pfirrmann分级，并测量髓核的T2弛豫时间值（T2值）。结果颈椎间盘髓核T2值与Pfirrmann分级负相关（r=－0.64，P＜0.01）。不同Pfirrmann分级椎间盘的髓核T2值差异有统计学意义（F=48.2，P＜0.01），各级间两两比较T2值差异均有统计学意义（P＜0.05）。T2值鉴别Ⅰ级与Ⅱ级、Ⅱ级与Ⅲ级、Ⅲ级与Ⅳ级椎间盘的ROC曲线下面积分别为0.79、0.81和0.78（P＜0.05）。18～30岁组髓核T2值大于31～40岁组（P＜0.05）。18～30岁组不同解剖节段的髓核T2值差异有统计学意义（P＜0.05）；而31～40岁组不同解剖节段的髓核T2值差异无统计学意义（P＞0.05）。结论 MRI测量T2弛豫时间值能量化评估颈椎间盘退变及其年龄、解剖节段相关变化，具有一定的临床价值，应作为评估颈椎间盘退变的补充序列。Abrtract Objective： To explore the value of T2 relaxation time （T2 value） measurement in detecting cervical intervertebral disc degeneration, and assessing age and disc level related intervertebral disc changes. Materials and Methods： Forty asymptomatic adult volunteers were examined at 1.5 T MR by T2-weighted sagittal imaging and T2-mapping. For all participants, Pfirrmann grading system and T2 value were used to evaluate the degenerative degree of the disks. Results：Signiifcant negative correlation were observed between Pifrrmann grades and T2 values of cervical intervertebral disc （r=-0.64, P〈0.01）. ANOVA （analysis of variance） among different Pfirrmann grades showed significant differences in T2 values （F=48.2,P〈0.01）, and signiifcant differences were seen between any 2 grades （P〈0.05）. The area under ROC curve of T2 value were 0.79, 0.81 and 0.78 （P〈0.05） separately when gradeⅠvs.Ⅱ,Ⅱvs.Ⅲ, andⅢvs.Ⅳ. T2 values of 18—30 age group were higher than 31—40 age group participants （P〈0.05）. Signiifcant differences among different disc level were observed in 18—30 age group （P〈0.05）. However, in 31—40 age group, no significant differences of disc level were demonstrated （P〉0.05）. Conclusions：T2 relaxation time measurement is a quantitative-parameter for assessing cervical intervertebral disc degeneration and age and disc level related disc changes, and shall be used as a complementary sequence in detecting cervical disc degeneration for its certain clinical value.

关 键 词：椎间盘退化 颈椎病 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R681.53[医药卫生—诊断学]