Eales病患者血清中PR3-ANCA和MPO—ANCA检测和临床意义  

Determination and clinical study of anti-PR3 and anti-MPO antibody with Eales disease

作　　者：周必业[1] 魏世辉[2] 

机构地区：[1]海军总医院全军航海航空医学中心,北京100048 [2]解放军总医院眼科,北京100853

出　　处：《中国实用眼科杂志》2015年第11期1231-1234,共4页Chinese Journal of Practical Ophthalmology

摘　　要：目的了解Eales病患者血清中PR3-ANCA和MPO-ANCA的含量，以及其在诊断和治疗中的意义。方法临床对照研究。于2009—2014年在解放军总医院眼科详细记录每份血清的患者所在分期，应用间接免疫荧光（IIF）法检0n,0ANCA总抗体，用ELISA法检测抗PR3抗体和抗MPO抗体。结果PR3抗体指标：首发组阳性率为54．3％（19／35），对照组阳性率为0，显著高于对照组，治愈组阳性率为11．5％（3／26），与对照组相比无明显统计学差异，治愈组阳性率显著低于首发组。MPO抗体：首发组阳性率为22．9％（8／35），对照组阳性率为0，显著高于对照组，治愈组阳性率为3．8％（3／26），首发组和治愈组之间无显著性差异。在Eales病分期的四个期，抗PR3抗体阳性率分别为50％（2／4），60％（6／10），66．7％（10／15）和16．7％（1／6）。结论ANCA在Eales病的诊断中具有肯定意义，有望成为Eales病诊断以及评价治疗效果的一个血清学标志。同时检测MPO抗体和PR3抗体诊断意义更大。Objective To learn Eales disease patients in a PR3 ANCA and MPO-ANCA of con- tent, and its significance in the diagnosis and treatment of Eales disease. Methods Detailed records of each serum where staging, indirect immunofluorescence （IIF） assay ANCA total antibody to detect anti-PR3 antibody and anti-MPO antibodies by ELISA. Results From PR3 antibody indicators, posi- tive first group was 54.3%, significantly higher. The positive rate of 11.5% cure, no significant differ- ence compared with the control group. The positive rate of cure was significantly lower than the first group. MPO antibodies from the point of view, the first group the positive rate of 22.9%, sig- nificantly higher. But there was no significant difference between the first group and the cure group. With the new staging system, four of the Eales disease was seen, anti-PR3 antibody positive rates were 50%, 60%, 66.7% and 16.7%. Conclusions ANCA has affirmed in the diagnosis of Eales dis- ease, there is hope to become Eales disease diagnosis as well as a serological marker to assess treat- ment effects. From clinical practice, detecting MPO antibodies and PR3 antibody is first choice.

关 键 词：抗中性粒细胞胞浆抗体 视网膜静脉周围炎 

分 类 号：R593.242[医药卫生—内科学]