针刺治疗急性加重期痰热壅肺型肺源性心脏病临床研究  

Clinical Research of Acupuncture in Treating Acute Stage of Pulmonary Heart Disease with Syndrome of Phlegm-Heat Obstructing Lung

作　　者：牛国平 康斐[2] 

机构地区：[1]焦作卫生医药学校附属医院,河南焦作454100 [2]河南中医学院第三附属医院,河南郑州450008

出　　处：《中医学报》2015年第11期1687-1689,共3页Acta Chinese Medicine

基　　金：河南省重点科技攻关项目(082102310080)

摘　　要：目的:观察针刺治疗肺心病急性加重期痰热壅肺证的临床疗效以及对血清白细胞介素-8(Interleukin,IL-8)和肿瘤坏死因子-α(tumor necrosis factor,TNF-α)水平的影响。方法:将114例患者按随机数字表法分为对照组和治疗组,每组57例。对照组采用西医常规治疗;治疗组在对照组治疗基础上加用针刺治疗。两组均每天1次,每周5次。两组均连续治疗4周。比较两组中医临床症状积分、肺动脉平均压和心输出量;检测两组血清IL-8和TNF-α水平。结果:治疗组治疗后中医临床症状评分均低于对照组,差异有统计学意义(P<0.01);对照组有效率为71.93%,治疗组有效率为89.47%,两组比较,差异有统计学意义(P<0.01);治疗组治疗后肺动脉压明显低于对照组,心输出量显著高于对照组,差异有统计学意义(P<0.01);治疗后,治疗组IL-8和TNF-α水平均显著高于对照组,差异有统计学意义(P<0.01)。结论:针刺治疗肺心病急性加重期痰热壅肺证疗效显著,并可显著改善临床症状,降低肺动脉压,提高心输出量,抑制患者血清IL-8和TNF-α表达水平。Objective ：To observe the therapeutic efficacy of acupuncture in treating acute stage of pulmonary heart disease with syndrome of phlegm-heat obstructing lung and its influences on serum levels of interleukin-8 （IL-8） and tumour necrosis factor-α（TNF-α）. Meth- ods ： 114 patients were randomly divided into the control group and the treatment group, each of 57 eases. The control group was given routine western therapy, and the treatment group was treated with acupuncture on the basis of control group. One time a day, five times a week. Continuous treatment for 4 weeks in both groups. After treatment,the scores of Chinese clinical symptoms, mean pulmonary artery pressure and cardiac output in the two groups were compared. Serum levels of IL-8 and TNF-α were measured in two groups. Results ： After treatment, the scores of Chinese clinical symptoms in the treatment group were evidently lower than control one（ P 〈 0. 01 ）. The effective rates of control group and treatment group were 71.93% and 89.47% respectively, and the treatment group was significantly higher than that of control group （P 〈 0.01 ）. After treatment mean pulmonary artery pressure for the treatment group was obviously lower than control group, and cardiac output was evidently higher than control group（ P 〈 0. O1 ）. After treatment, IL-8 and TNF-α levels in the treatment group were evidently higher than those of control group, and the difference was statistically significant （P 〈 0.01 ）. Conclusion ： Acupuncture in treating acute stage of pulmonary heart disease with syndrome of phlegm-heat obstructing lung could evidently improve clinical symptoms, reduce the pulmonary hypertension and improve cardiac output. And one of possible mechanisms may be relat ed with suppressing the expressions of serum levels IL-8 and TNF-α.

关 键 词：肺源性心脏病 痰热壅肺证 针刺疗法 白细胞介素-8 肿瘤坏死因子-Α 

分 类 号：R245.415[医药卫生—针灸推拿学]