支气管哮喘患儿呼出气一氧化氮的变化及其与肺功能的相关性  

The correlation between the changes of exhaled nitric oxide and lung function in asthmatic children

作　　者：丁静[1] 赵德育[1] 吴美思[1] 

机构地区：[1]南京医科大学附属南京儿童医院呼吸科,210008

出　　处：《中华实用儿科临床杂志》2015年第22期1729-1731,共3页Chinese Journal of Applied Clinical Pediatrics

摘　　要：目的探讨呼出气一氧化氮（FeNO）在支气管哮喘（哮喘）患儿各期中的变化及其与肺功能的相关性和临床意义。方法选择在南京医科大学附属南京儿童医院哮喘门诊就诊的6～14岁的哮喘患儿79例，其中急性发作期25例，慢性持续期28例，缓解期26例。简单随机抽样选取健康儿童25例作为健康对照组，分别测定其FeNO和肺功能，分析FeNO和肺功能在各组受试对象之间差异是否存在统计学意义，并比较其FeNO与肺功能指标是否存在相关性。结果FeNO、1秒钟用力呼气容积占预计值百分比（FEV1％）在哮喘急性发作期[（58．79±12．25）ppb和（52．25±7．89）％]、慢性持续期[（42．13±11．38）ppb和（66．14±5．29）％]、缓解期[（25．41±7．15）ppb和（86．22±15．21）％]及健康对照组[（12．84±6．22）ppb和（93．62±12．13）％]之间比较，FeNO在哮喘急性发作期组、慢性持续期组、缓解期组水平均较健康对照组高，差异均有统计学意义（P均〈0．05）。FEV1％除在缓解期与健康对照组比较差异无统计学意义（P〉0．05）外，余差异均有统计学意义（P均〈0．05）。急性发作期FeNO与FEV1％呈负相关（r=-0．779，P=0．000），慢性持续期及缓解期的FeNO与FEV1％无相关性。结论哮喘患儿FeNO水平增高，FeNO是反映呼吸道炎症的灵敏指标，可用来评价呼吸道炎症的控制情况和病情轻重程度。急性发作期哮喘患儿FeNO与肺功能中FEV1％呈负相关。Objective To investigate the correlation with lung function and clinical significance of lung function and exhaled nitric oxide （FeNO） changes in various disease stages for children with asthma. Methods Seventy - nine asthma outpatient children aged 6 - 14 years old were selected from Nanjing Children＇s Hospital Affiliated to Nanjing Medical University ,25 cases of whom were at acute exacerbation stage ,28 cases at chronic persistent stage and 26 cases at remission stage. Twenty-five healthy children were randomly selected as the healthy control group, for whom FeNO and lung functions were measured respectively. FeNO and lung functions were analyzed on whether there were statistical differences between the subjects in these groups and whether their FeNO and lung functions were correlated. Results Comparison of FeNO and the percentages of the expected value （ FEV1% ） of forced expiratory volume in one second between acute exacerbation group [ （58.79 ± 12.25 ） ppb and （52.25 ± 7.89 ）% ] , chronic persistent group [ （42.13 ± 11.38） ppb and （66.14 ± 5.29）% ] ,remission group[ （25.41 ± 7.15 ） ppb and（86.22 ± 15.21 ）% ] and the healthy control group[ （ 12.84 ± 6.22） ppb and （93.62 ± 12.13 ） % ] ,showed that FeNO in asthma acute exacerbation group, chronic persistent group and remission group was higher than that in the healthy control group, with statistically significant difference（ all P 〈 0.05 ）. Except for remission group, in which FEV1 was not statistically significant different from the healthy control group （P 〉 0. 05 ）, the differences in other groups were all statistically significant（ all P 〈 0. 05 ）. FeNO and FEV1% were negatively correlated at acute exacerbation （r = -0. 779, P = 0. 000 ）, but they were not correlated at chronic persistent and remission state. Conclusions FeNO values increased in asthma children. FeNO as a sensitive indicator to reflect airway inflammation can be used to evaluate the control and severity of airway infla

关 键 词：支气管哮喘 呼出气一氧化氮 肺功能 一秒钟用力呼气容积占预计值百分比 

分 类 号：R725.6[医药卫生—儿科]