增加氧饱和度对肺肿瘤组织摄取^(99m)锝-甲氧基异丁基异腈亲肿瘤显像的临床研究  

Study on the clinical value of oxygen saturation increase on lung tumor tissue uptaking ^(99m)Tc-MIBI tumoraffin imaging

作　　者：刘超[1] 李骏鹏 陆建梅[1] 刘鹏杰[1] 贾莉[1] 邓智勇[1] 

机构地区：[1]云南省肿瘤医院(昆明医科大学第三附属医院)核医学科,云南昆明650118

出　　处：《中国现代医学杂志》2015年第31期85-87,共3页China Journal of Modern Medicine

基　　金：云南省教育厅研究项目(No:2013Y282)

摘　　要：目的探讨增加氧饱和度对肺肿瘤组织摄取^(99m)锝-甲氧基异丁基异腈亲肿瘤显像(^(99m)Tc-MIBI)的临床价值。方法 21例肺癌患者吸氧前后分别行单光子发射计算机断层成像术(SPECT)早期(吸氧前)和延迟(吸氧后)断层显像,计算早期相摄取比值(ER)和延迟相摄取比值(DR),分析吸氧前后ER值、DR值及氧饱和度的差异。结果早期ER和DR值分别为(2.06±0.62)和(2.45±0.71),吸氧后ER和DR值分别为(2.70±0.69)和(3.54±0.87)。吸氧后ER和DR值较吸氧前显著提高,差异有统计学意义(P<0.05)。吸氧前氧饱和度为(89.5±4.5)%,吸氧后氧饱和度为(96.3±2.5)%,吸氧后氧饱和度明显上升,差异有统计学意义(P<0.05)。结论增加氧饱和度对肺肿瘤组织摄取^(99m)Tc-MIBI有较高的临床价值。[ Objective ] To discuss the clinical value of oxygen saturation increase on lung tumor tissue uptaking ^99mTc-MIBI tumoraffin imaging. [Methods] Conduct ^99mTc-MIBI lung tumor SPECT early stage and delayed fault imaging to 21 lung tumor patients before and after their oxygen inhalation, calculate early stage lung tumor/non lung tumor tissue uptaking ratio （ER）, and make statistics about the difference of ER, DR and oxygen saturation before and after oxygen inhalation. [ Results ] In the early stage, the mean values of ER and DR before oxygen inhalation are （2.06 ± 0.62） and （2.45 ± 0.71） respectively, and after oxygen inhalation, the mean values of ER and DR are （2.70 ± 0.69） and （3.54 ± 0.87） respectively, so the mean values of ER and DR remarkably rise after oxygen inhalation than those before oxygen inhalation, and the two have statistical significance （P 〈 0.05）. The mean values of oxygen saturation before and after oxygen inhalation are （89.5 ± 4.5）% and （96.3 ± 2.5）% respectively, and oxygen saturation goes up obviously after oxygen inhalation, and the two have statistical significance （P 〈 0.05）. [ Conclusion ] Increasing oxygen saturation has pretty high clinical value for lung tumor tissue uptaking ^99mTc-MIBI.

关 键 词：吸氧 ^99M锝-甲氧基异丁基异腈 氧饱和度 显像剂 

分 类 号：R817.4[医药卫生—影像医学与核医学] R734.2[医药卫生—放射医学]