化浊解毒法治疗慢性萎缩性胃炎疗效的Meta分析  

Meta-analysis of Therapeutic Effect of Removing Turbidites and Detoxication Method in Treating Chronic Atrophic Gastritis

作　　者：王彦刚[1] 刘宇[2] 李佃贵[1] 

机构地区：[1]河北省中医院 [2]河北中医学院

出　　处：《中医杂志》2015年第23期2017-2020,共4页Journal of Traditional Chinese Medicine

基　　金：河北省科学技术研究与发展计划(10276103D)

摘　　要：目的运用Meta分析对应用化浊解毒法治疗慢性萎缩性胃炎（CAG）的疗效进行系统评价。方法检索中国期刊全文数据库、维普中文期刊数据库、中国博士学位论文全文数据库、中国优秀硕士学位论文全文数据库、中国重要会议论文全文数据库、国际会议论文全文数据库,纳入以化浊解毒法为指导运用中药为主与西药或常见中成药对照治疗CAG的随机对照试验。由2名评价员按Jadad评分法对纳入的文献进行质量评价并进行资料提取,采用RevMan 5.2.0软件对临床有效率及胃镜病理改善率进行Meta分析。结果共纳入11篇研究,所有纳入文献的Jadad评分均为1-2分。Meta分析结果显示,运用化浊解毒法以中药为主治疗CAG,临床有效率[加权RR=1.33,95%CI（1.22,1.45）,P〈0.001（10篇文献）]及胃镜改善率[加权RR=1.37,95%CI（1.18,1.61）,P〈0.001（6篇文献）]均优于对照疗法。结论化浊解毒法治疗CAG临床疗效及胃镜疗效优于其他对照治疗方法,但纳入文献的质量较低,确切结论尚需更高质量的试验证实。Objective Using Meta-analysis,to make systematical review of the therapeutic effect of applying removing turbidites and detoxication method treating chronic atrophic gastritis（ CAG）. Methods Reviewed all literature from Journal Full-Text Database of China National Knowledge Infrastructure（ CNKI）,VIP Data,the full text database of Chinese doctoral dissertation,the full text database of Chinese outstanding master＇ s dissertation,the full text database of Chinese important conference papers and the full text database of international conference papers.Randomized controlled trials,guided by removing turbidites and detoxication method,treating CAG by Chinese medicine mainly and controlled with western medicine or common Chinese patent medicine,were included. Two evaluation members made quality evaluation of included papers by Jadad score method and extracted data. Make Meta analysis of the clinical effective rate and gastroscopic pathological improving rate adopting the software of Rev Man 5. 2. 0.Results Eleven researches were included,whose Jadad scores were all 1- 2. Meta analysis results showed that the clinical effective rate [weighing RR = 1. 33,95% CI（ 1. 22,1. 45）,P〈 0. 001（ 10 papers） ]and gastroscopic improving rate [weighing RR = 1. 37,95% CI（ 1. 18,1. 61）,P〈 0. 001（ 6 papers） ] adopting removing turbidites and detoxication method treating CAG by Chinese medicine mainly were both superior to those by controlled therapy.Conclusion The clinical and gastroscopic effect of removing turbidites and detoxication method in treating CAG was superior to other controlled therapeutic methods. The included papers were relatively low quality. High quality trials are needed to make a certain conclusion.

关 键 词：慢性萎缩性胃炎 化浊解毒法 系统评价 META分析 

分 类 号：R259[医药卫生—中西医结合]