受体介导的主动靶向壳聚糖衍生物递药载体的研究进展  

Research progress of receptor-mediated active targeting chitosan drug carriers

作　　者：孙川[1] 梁云星[1] 郑颖[1] 王宁[1] 梁桂贤[1] 

机构地区：[1]山西医科大学,太原030001

出　　处：《中国新药杂志》2015年第22期2584-2588,共5页Chinese Journal of New Drugs

基　　金：山西省自然科学基金(2014011047-4)

摘　　要：壳聚糖作为一种新型药物载体,在提高抗癌药物的递送效率上发挥着重要的作用,近年来通过多种配体与壳聚糖发生化学反应,对壳聚糖进行结构修饰得到受体介导的主动靶向的壳聚糖衍生物递药载体材料,为靶向制剂的研究奠定了基础。本文就近年来介导主动靶向的受体、相应的配体、靶向机制和主动靶向的壳聚糖衍生物递药载体的研究现状进行综述。Chitosan, as a new drug carrier, plays a crucial role in improving the delivery efficiency of anti- cancer drugs. Chitosan is modified by a variety of ligands to obtain receptor-mediated active targeting; this has pro- vided references for the study of targeting agent in recent years. In this paper we reviewed the latest research pro- gress of receptors used in active targeting therapy, corresponding ligands, targeting mechanism and active targeting carriers of chitosan derivatives.

关 键 词：壳聚糖 受体 主动靶向 递药载体 

分 类 号：R979.1[医药卫生—药品]