抗胆碱药盐酸戊乙奎醚减慢心率及影响心率变异性的初步观察  

Effect of the anticholinergic agent penehyclidine hydrochloride on retarding heart rate and ameliorating heart rate variability in healthy volunteers

作　　者：雍小兰[1] 胡婷婷[1] 李楠[1] 杜晓琳[1] 王蓝天[1] 康辉[1] 

机构地区：[1]中国人民解放军成都军区总医院,成都610083

出　　处：《中国新药杂志》2015年第22期2594-2598,共5页Chinese Journal of New Drugs

摘　　要：目的：观察抗胆碱药盐酸戊乙奎醚（penehyclidine hydrochloride,PH）对健康受试者心率及心率变异性的作用,初步探讨其对自主神经活动的影响。方法：健康受试者26例,男女各半,年龄20~30岁,随机分为0.3,0.4,0.6,0.8和1.0 mg PH组,单次给药。每个剂量组随机选择2例（男女各1例）受试者行24 h动态心电图监测,采集健康受试者给药前后24 h的平均心率及心率变异性时域参数（SDNN,SDNN Idx,r MSSD,SDANN,p NN50,TI）;其余16例受试者采用常规心电图监测记录给药前后24 h心率。比较给药前后24 h心率,并采用心率变异性（heart rate variability,HRV）时域分析法考察心率变异性的变化。结果：PH给药后,常规心电图显示受试者心率明显减慢（P〈0.05）;动态心电图监测结果表明受试者24 h平均心率与给药前相比显著减慢（P〈0.01）,1 h SDNN显著提升（P〈0.01）,24 h长程SDNN,SDNN Idx,r MSSD,p NN50和TI水平较给药前呈上升趋势;SDANN水平略低于给药前。结论：PH可能通过非M2受体或增强迷走神经张力影响HRV,进而减慢心率。Objective： To observe effect of penehyclidine hydrochloride （PH） on heart rate and heart rate variability as well as its activity on autonomic nervous system in healthy volunteers. Methods： A total of 26 healthy volunteers were enrolled in a randomized, opened study. They were randomized to be divided into 5 groups and o- rally received PH 0.3 ~ 1.0 mg daily. Two healthy volunteers were selected from each group and monitored by dy- namic electrocardiography recording 24-h average heart rate; parameters of time domain including SDNN, SDNN Idx, SDANN, rMSSD, pNN50 and TI were analyzed for evaluating heart rate variability. Other 16 healthy volun- teers accepted routine electrocardiography to record heart rate. Data from average heart rate and parameters of heart rate variability befoe and after oral PH were analyzed by professional software. Results： Compared with baseline level, average heart rate of healthy subjects within 24 h was significantly retarded after PH administration （P 〈 0.01） , and SDNNs were significantly increased （P 〈 0.01 ） in 5 PH dose groups. Other parameters including SDNN Idx, rMSSD, pNN50 and TI were slightly prolonged, and SDANN was shortened a little （P 〈 0.05）. Con- clusion： PH retards heart rate, which may be mediated by the way of non-M2 receptor or strengthened vagal tone.

关 键 词：盐酸戊乙奎醚 心率变异性 心率 动态心电图 抗胆碱药 

分 类 号：R971.2[医药卫生—药品]