慢性阻塞性肺疾病患者肺功能曲线α角与BODE指数的关系  

Relationship between alpha angle of pulmonary function curve and BODE index in patients with chronic obstructive pulmonary disease

作　　者：王印林 张明生[1] 张厚亮[1] 刘永岭[1] 

机构地区：[1]天津医科大学静海临床学院呼吸科,天津301600

出　　处：《临床荟萃》2015年第11期1254-1257,共4页Clinical Focus

基　　金：天津市卫生局课题(2011KZ09)

摘　　要：目的对先前提出的一个描述气流阻塞程度的参数α角进一步验证其合理性,探讨此参数与BODE指数在慢性阻塞性肺疾病(COPD)患者中的关系。方法于2010年1月至2012年3月,电话随诊稳定期COPD患者,以肺功能指标为标准分为轻度阻塞、中度阻塞、重度阻塞3组,然后各组分别随机选取患者35例,查改良的英国医学研究委员会呼吸困难量表(MMRC)呼吸困难评分、6分钟步行距离(6MWD),计算BODE指数;测量α角。结果COPD患者α角随着阻塞程度的加重逐渐变小,对应的流速和呼出气量与呼气1秒时的流速和呼出气量呈正相关,α角大小与BODE指数呈负相关。结论α角可一定程度上反映COPD患者气流阻塞程度、肺功能曲线形态、运动耐量水平。Objective To further verify the rationality of the parameter alpha angle previously proposed which describes the degree of airflow obstruction,and to discuss the relationship between the parameter and BODE index in patients with chronic obstructive pulmonary disease（COPD）.Methods From January 2010 to March 2012,the patients with stable COPD were followed through telephone.By using pulmonary function index,the patients were divided into three groups：mild,moderate and severe obstruction.Then,35 patients were randomly selected from each group,Modified Medical Research Council Scale（MMRC）difficulty breathing scale,6 minute walk distance（6MWD）,and BODE index were calculated,and the alpha angle was measured.Results The alpha angle in the patients with COPD decreased with the increase of obstruction.The flow rate and breath volume corresponding to alpha angle were positively related to those when the patients exhaled one second.The size of alpha angle was negatively correlated with BODE index.Conclusion To some extent,the alpha angle can reflect the degree of airflow obstruction,the shape of the lung function curve,and the level of exercise tolerance in COPD patients.

关 键 词：肺疾病 慢性阻塞性 呼吸功能试验 最大呼气流量-容积曲线 

分 类 号：R563.3[医药卫生—呼吸系统]