蚁皇口服液对小鼠免疫性肝损伤的保护作用  

Studies of the Protective Effect of Oral Yihuang Liquor on Immune Liver Injury in Mice

作　　者：顾卫 刘进学[2] 袁盛榕[2] 詹元红 赵敏 

机构地区：[1]广东省惠州市中医院,惠州市516001 [2]首都医科大学药理教研室,北京市100054 [3]北京市中医院,北京市100006

出　　处：《中国药房》2002年第8期461-463,共3页China Pharmacy

摘　　要：研究蚁皇口服液对小鼠免疫性肝损伤的保护作用。方法 :小鼠分别尾静脉注射卡介苗 +脂多糖造摸 ,灌胃给予蚁皇口服液后检测小鼠血清中ALT、AST及肝、脾重量 ,并在光镜下观察给药前、后小鼠肝损伤的病理变化。结果 :大、中剂量蚁皇口服液可明显降低肝损伤小鼠的血清ALT、AST ,使肿大的肝、脾缩小 ,光镜下可见小鼠肝细胞变性、坏死程度及肝实质与汇管区的炎细胞浸润明显减轻。小剂量蚁皇口服液一方面可抑制正常或亢进的小鼠细胞免疫功能 ,使小鼠迟发性超敏反应减轻 ;另一方面也可提高低下的小鼠细胞免疫功能 ,使小鼠迟发性超敏反应增强。结论 :蚁皇口服液具有调节细胞免疫的功能 ,对免疫性肝损伤确有明显的保护作用。OBJECTIVE:To study the protective effect of oral Yihuang liquor on the immune liver injury of mice METHODS:The mouse models were established by injecting BCG+LPS qd through caudal veins on 10 successive days,then Yihuang liquor was given to mice through gastric tube The serum ALT,AST and weight of liver and spleen were determined,and the pathological changes of the liver were observed under light microscope before and after administration of Yihuang liquor RESULTS:Yihuang liquor in a large dose or middle dose could markedly decrease the levels of serum ALT and AST,lessen the swelling of liver and spleen,reduce the degeneration and necrosis of hepatic cells and inflammatory cell infiltration in portal area in mice with liver damage On one hand Yihuang liquor in a low dose could inhibit the immunofunction and alleviate delayed hypersensitive reaction in mice with normal or enhanced cellular immunofunction but on the other it could raise immunofunction and enhance the delayed hypersensitive reaction in mice with hypoimmunofunction CONCLUSION:Yihuang liquor can regulate cellular immunofunction and obviously protect the immune liver injury

关 键 词：蚁皇口服液 迟发性超敏反应 免疫性肝损伤 保护作用 慢性乙型肝炎 免疫药理学 

分 类 号：R259.126.2[医药卫生—中西医结合] R285[医药卫生—中医内科学]