苦豆子栓剂的研制及临床应用  

Preparation and Clinical Application of Sophora Alopecurodies Suppository

作　　者：任棣[1] 常威[1] 白进良[1] 

机构地区：[1]兰州医学院附属第一医院,兰州市730000

出　　处：《中国药房》2002年第8期468-469,共2页China Pharmacy

基　　金：甘肃省科技厅资助项目 (QS002-C33-010)

摘　　要：目的 :研制治疗慢性前列腺炎的栓剂并考察其临床疗效。方法 :以苦豆子总生物碱 (TASa)为主药 ,用酸性染料分光光度法测定TASa的含量 ,并与前列安栓进行对照 ,观察其临床疗效。结果 :TASa的线性范围为0 14～15 4μg/ml,氧化苦参碱对照品的加样回收率为101 2 % ,RSD=0 55 %。结论 :该制剂制备工艺简单 ,质控方法可靠 ;对直肠刺激性小 ,临床疗效确切 ,值得临床推广应用。OBJECTIVE:To prepare Sophora alopecurodies suppository for treating prostatitis chronica and observe its clinical therapeutic effect METHODS:The content of the total alkaloid in the suppository was determined with acid dye spectrophotometry and the therapeutic effect was observed in comparison with qianliean suppository RESULTS:The linear range of TASa was 0 14～15 4μg/ml,standard oxymatriner's recovery was 101 2%,RSD=0 55% CONCLUSION:This suppository is simple in preparation,reliable in quality-control It is slight in irritation to rectum and effective in clinical use The preparation is worth popularizing in clinical practice

关 键 词：苦豆子栓剂 苦豆子总生物碱 栓剂 质量控制 临床应用 慢性前列腺炎 

分 类 号：R277.573.3[医药卫生—中医学] R283