法莫替丁分散片的研制及体外溶出特性  

Preparation and in Vitro Dissolution Characteristics of Famotidine Dispersible Tablets

作　　者：张建春[1] 王原[1] 陈鼎继[1] 王春宏[1] 温亚旭[2] 

机构地区：[1]解放军第一医院药剂科,兰州市730030 [2]兰州医学院药学系

出　　处：《中国药房》2002年第8期473-474,共2页China Pharmacy

摘　　要：目的 :研制法莫替丁分散片 ,并考察其体外溶出特性。方法 :采用正交设计方法优选出制备的最佳条件。结果 :本品在1min内可完全崩解 ;体外溶出度表明 ,T50=0 56min。结论 :用优选处方制备的法莫替丁分散片比市售片崩解快 ,分散均匀。OBJECTIVE:To study the preparation of famotidine dispersible tablets and to observe the dissolution characteristics in vitro METHODS:To optimize the conditions for preparation by orthogonal design RESULTS:The tablets could completely disintegrate within 1 min;In vitro dissolution test showed T50=0 56min CONCLUSION:In comparison with commercial famotidine tablets,the dispersible tablets prepared in optimum condition were rapid in disintegration and homogenous in dispersal

关 键 词：法莫替丁 分散片 正交设计 溶出度 

分 类 号：R943[医药卫生—药剂学]