Orbitrap Fusion Lumos：基于Q-OT-qIT平台的第二代“三合一”超高分辨质谱  

Orbitrap Fusion Lumos： Second Generation of ＂Tribrid＂ UHR-MS Based Q-OT-qlT

作　　者：张伟[1] 

机构地区：[1]赛默飞世尔科技(中国)有限公司,上海201206

出　　处：《现代科学仪器》2015年第5期76-78,共3页Modern Scientific Instruments

摘　　要：Orbitrap Fusion Lumos是基于Q-OT-qIT平台的第二代“三合一”质谱，通过离子入口、离子透镜、四极杆、ETD和真空技术等方面的深度改进，将仪器整体性能优化至极致。配合“三合一”质谱魔法般的功能，Orbitrap Fusion Lumos能够有效应对蛋白质组学和代谢组学最复杂的分析挑战。本文从定性定量极限灵敏度、抗污染性能、翻译后修饰和top-down解析等方面，介绍了第二代“三合一”质谱的性能突破和应用进展。Orbitrap Fusion Lumos is the second generation of＂Tribrid＂ MS based on Q-OT-qlT system. The ion inlet, ion optics, quadrupole, ETD and vacuum system are deeply improved, and the instrument performance is extremely optimized. Combined with various magic functions on ＂Tribrid＂, the new system can effectively face the extreme challenge in proteomics and metabolomics. This paper introduces the improvements and advances of the new ＂Tribrid＂ MS, including enhanced qual/quan sensitivity, robustness, PTM elucidation and top-down analysis.

关 键 词：ORBITRAP FUSION Lumos 蛋白质组学 代谢组学 TOP-DOWN 

分 类 号：TH843[机械工程—仪器科学与技术]