胰岛素样生长因子2和H19基因印迹的机制及其印迹异常与疾病的关系  

The imprinting mechanism of IGF2 and H19 and the correlation between their imprinting changes and disease

作　　者：徐海燕[1] 王树人[2] 李丽娟[1] 

机构地区：[1]遵义医学院病理生理学教研室,贵州遵义563099 [2]四川大学基础医学院病理生理学教研室,四川成都610041

出　　处：《遵义医学院学报》2015年第5期549-554,共6页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:81260131);贵州省科学技术基金资助项目(NO:黔科合J字[2010]2277);遵义医学院博士科研启动基金资助项目(NO:F-460)

摘　　要：胰岛素样生长因子2(IGF2)和H19是连锁交互印迹的基因,二者对细胞的增殖发挥重要的调控作用。IGF2和H19的印迹控制区包括IGF2基因内的差异甲基化区(DMR)和H19上游的DMR,这些DMR甲基化状态改变所导致的IGF2和H19印迹表达紊乱是肿瘤等增殖性疾病的重要发病机制;另外,绝缘蛋白CCCTC结合分子(CTCF)及类CTCF(BORIS)也参与了IGF2和H19的印迹调控,二者的表达紊乱同样也可造成IGF2和H19的印迹改变及表达紊乱。无论IGF2的印迹丢失还是H19的印迹丢失都参与了肿瘤等增殖性疾病的发生,该机制对这些疾病的影响越来越受到关注。本文总结了近年来的资料,阐述了IGF2和H19印迹的机制,分析了IGF2和H19的印迹状态改变与疾病的关系。Insulin -like growth factor 2 （IGF2） and H19 are two reciprocally imprinted genes located adjacent to each other. They are important regulating molecules of cell proliferation. The imprinting control regions of IGF2 and H19 include the differentially methylated region （DMR） of IGF2 and the upstream of the H19. These methylation status changes of DMR are important mechanisms of imprinting expression disorder of IGF2 and H19 in the pathological processes of tumor and other proliferative diseases. In addition, the imprinting of IGF2 and H19 is also affected by CCCTC molecules （CTCF） and brother of the regulator of imprinted sites （BORIS）. Their abnormal expression is involved in the imprinting expression disorder of these two genes. The imprinting loss of H19 or IGF2 is closely related with the pathogenesis of tumor and other proliferative diseases. The roles they played in the pathogenesis of proliferative diseases attract more and more attention recently. This article reviewes the imprinting mechanism of IGF2 and H19 and the correlation between their imprinting changes and diseases.

关 键 词：印迹基因 差异甲基化区 印迹丢失 胰岛素样生长因子2 H19 

分 类 号：Q754[生物学—分子生物学]