肺功能检测在肺结核患者中的性别差异  

Gender difference of pulmonary function testing in patients with pulmonary tuberculosis

作　　者：张鑫[1] 赵涛 高伟[1] 

机构地区：[1]河北省石家庄市第五医院结核一科,050000 [2]河北省定州市北城区卫生服务中心,073000

出　　处：《检验医学与临床》2015年第22期3309-3311,共3页Laboratory Medicine and Clinic

基　　金：河北省科技厅科技计划项目(132777178)

摘　　要：目的利用肺功能检测探讨性别等因素对肺结核患者肺功能的影响,以期对肺结核患者的防治提供借鉴。方法选取在2013年7月至2014年7月入住的肺结核患者为研究对象,采集其一般资料如年龄、性别、婚姻、教育程度等,分别于2013年和2014年进行两次肺功能检查,测定指标包括:(1)用力肺活量(FVC)体积及其占预测值的百分比,(2)第1秒用力呼气容积(FEV1)体积及其占预测值百分比,(3)1秒率(FEV1/FVC),(4)RV(L),(5)DLCO(%),(6)TLC(L)。运用t检验、方差分析、χ2检验,Logistic回归分析进行统计学处理。结果浸润型肺结核患者的肺功能基本正常,而慢性纤维空洞型肺结核患者的肺功能普遍异常,差异有统计学意义(P<0.05)。采用Logistic回归分析,年龄、吸烟和性别均是肺功能损伤加重的危险因素,OR值分别为1.03、1.34、1.01。结论肺结核的肺功能障碍呈混合性,同时更进一步说明早期根治肺结核的重要性,以避免肺的正常结构被破坏,浸润型转化成慢性纤维空洞型,造成肺功能不可逆的损害。年龄大、吸烟和女性肺结核肺功能损伤较重。其中不同性别肺结核患者的肺功能障碍,男性患者肺功能各项指标均高于女性。Objective To investigate the influence of the factors of gender,etc.on the pulmonary function in tuberculosis by the lung function test in order to provide reference for the prevention and treatment of the tuberculosis（TB）patients.Methods The patients with pulmonary TB admitted to our hospital from July 2013 to July 2014 were selected as the study subjects.Their general data such as age,gender,marital status,educational status were collected.Twice pulmonary function tests were performed in 2013 and 2014respectively,the measurement indicators including（1）the forced vital capacity（FVC）volume and its percentage of the predicted value;（2）forced expiratory volume in 1second（FEV1）volume and its percentage of the predicted value;（3）1seconds ratio（FEV1/FVC）;（4）RV（L）;（5）DLCO（%）;（6）TLC（L）.The statistical processing was performed by using t test,ANOVA,chi-square test,logistic regression analysis.Results The lung function in the patients with infiltrative pulmonary TB was basically normal,while which in the patients with chronic fibrocavitary pulmonary TB was usually abnormal,the difference was statistically significant（P〈0.05）.The Logistic regression analysis showed that age,smoking and sex were the risk factors for the aggravation of lung function injury,the OR values were 1.03,1.34 and 1.01 respectively.ConclusionThe pulmonary dysfunction in pulmonary TB is mixed,meanwhile which further reveals the importance of early eradicating pulmonary TB for avoiding the damage of the normal lung structure and infiltrative pulmonary TB converting to chronic fibrocavitary pulmonary TB causing irreversible damage to lung function.The pulmonary function damage is serious in the advanced age,smoking and female TB.In the TB pulmonary dysfunction,the various indexes in the male TB patients are higher than those in female TB patients.

关 键 词：肺结核 肺功能 慢性纤维空洞型 

分 类 号：R521[医药卫生—内科学]