非霍奇金淋巴瘤患者的乙型肝炎病毒感染率分析  

Analysis on hepatitis B virus infection rate in patients with non-Hodgkin lymphoma

作　　者：张扬 李明[1] 邓芳[1] 陈少华[1] 张家云[1] 

机构地区：[1]安徽省肿瘤医院检验科,合肥230031

出　　处：《检验医学与临床》2015年第22期3348-3350,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨非霍奇金淋巴瘤(NHL)患者中乙型肝炎(乙肝)病毒(HBV)的感染率。方法统计2012年9月至2014年12月住院的201例NHL确诊患者的乙肝5项标志物阳性率,并与388例同期住院的肺癌患者和325例体检中心健康体检者对比。结果 201例NHL患者HBsAg阳性率和"小三阳"[HBsAg(+)、HBeAb(+)及HBcAb(+)]发生率分别为16.9%和14.9%,明显高于肺癌患者(8.8%和8.2%)和健康体检者(5.2%和4.6%),差异均有统计学意义(P<0.05)。NHL患者HBsAb阳性率为45.3%,明显低于肺癌患者(57.2%)和健康体检者(55.4%),差异均有统计学意义(P<0.05)。B细胞型NHL的HBsAg阳性率高于T细胞型NHL(P<0.05),且HBsAb阳性率低于T细胞型NHL(P<0.05),但性别、年龄的差异均无统计学意义(P>0.05)。59例NHL患者HBV DNA阳性率为27.1%,其中HBsAg阳性患者阳性率为47.1%,HBsAg(-)伴HBcAb(+)的25例患者中有1例(4.0%)HBV DNA阳性。结论 NHL患者的HBV感染率高于肺癌患者和健康体检人群,特别是B细胞型NHL患者。NHL与HBV感染存在一定相关性,不能忽视NHL患者HBV隐匿性感染的情况。Objective To investigate the hepatitis B virus（HBV）infection rate in the patients with nonHodgkin lymphoma（NHL）.Methods The positive rates of HBV 5markers in 201 patients with NHL admitted to our hospital from September 2012 to December 2014 were performed the statistics and compared with those in 388 contemporaneous inpatients with lung cancer and 325 healthy persons undergoing the physical examination in the physical examination center.Results The HBsAg-positive rate and the simultaneously positive rate of HBsAg,HBeAb and HBcAb in 201 cases of NHL were 16.9% and 14.9%respectively,which were higher than those in the lung cancer patients（8.8% and 8.2%）and healthy persons undergoing the physical examination（5.2% and 4.6%）,the differences were statistically significant（P〈0.05）.The positive rate of anti-HBsAb was 45.3% in the NHL patients,which was significantly lower than 57.2% in the lung cancer patients and 55.4% in healthy persons,the differences were statistically significant（P〈0.05）.Compared with the T-cell NHL,the B-cell NHL had significantly higher positive rate of HBsAg and lower positive rate of HBsAb,but there were no statistically significant differences in sex and age（P〉0.05）.The HBV DNA positive rate was 27.1%in 59 cases of NHL,and was 47.1%in 34 cases of HBsAg-positive NHL,while 1case（4.0%）in 25 cases of HBsAg-negative and HBcAb-positive NHL.Conclusion The infection rate of HBV in NHL patients is significantly higher than that in the lung cancer patients and healthy persons,especially in the B-cell NHL.There is a certain correlation between NHL and HBV infection,and the occult HBV infection in NHL patients can not be ignored.

关 键 词：非霍奇金淋巴瘤 乙型肝炎病毒 隐匿性感染 

分 类 号：R512.62[医药卫生—内科学]