计划性剖宫产预防使用抗生素的临床分析  

Clinical analysis on prophylactic use of antibiotics for planned cesarean section

作　　者：吴晓娟[1] 彭方亮[1] 周晓[1] 郑姣妮[2] 

机构地区：[1]重庆市急救医疗中心妇产科,400014 [2]重庆市急救医疗中心药剂科,400014

出　　处：《检验医学与临床》2015年第22期3354-3356,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨计划性剖宫产预防抗生素合理应用方案。方法 2013年7月至2014年6月的计划性剖宫产200例分为观察组和对照组,每组100例,观察组将注射用头孢唑林钠1.0g溶于生理盐水100mL中于断脐后一次静脉滴注;对照组注射用头孢替安1.0g溶于生理盐水100mL中静脉滴注,首剂始于术前0.5h,每日2次,连用2d,观察术后两组体温、产褥病率、切口感染、子宫感染、呼吸泌尿系统感染发生及费用情况。结果两组术后最高体温、产褥病率、切口感染、子宫感染、呼吸泌尿系统感染率差异无统计学意义(均P>0.05)。但观察组抗生素费用明显少于对照组,差异有统计学意义(P<0.05)。结论计划性剖宫产使用头孢菌素第1代断脐后单次给药是一种合理、有效、经济的方案。Objective To discuss the rational application scheme of prophylactic antibiotic use in planned cesarean section.Methods 200 cases of planned cesarean section from July 2013 to June 2014 were divided into the observation group and the control group,100 cases in each group.The observation group was given cefamezin 1g dissolving in normal saline 100 mL by once intravenous drip immediately after cutting off the umbilical cord.The control group was given cefotiam 1.0g dissolving in normal saline 100 mL by intravenous drip,the initial dose was given at preoperative 30 min,twice a day for consecutive 2d.The body temperature,puerperal morbidity,incision infection,uterine infection,respiratory and urogenital system infection and costs were compared between the two groups.Results The highest body temperature,puerperal morbidity,incision infection,uterine infection,respiratory and urogenital system infection after operation had no statistical differences between the two groups（P〉0.05）.The antibiotic cost of the observation group was significantly less than that of the control group,and the difference was statistically significant（P〈0.05）.Conclusion The single-dose application of first generation cephalosporin after cutting off the umbilical cord for planned cesarean section can be regarded as a kind of reasonable,effective and economical scheme.

关 键 词：计划性剖宫产 头孢唑林 头孢替安 

分 类 号：R978.1[医药卫生—药品]